ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2018
Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Transcriptome-wide association study of circulating IgE levels identifies novel targets for asthma and allergic diseases.Frontiers in immunology · 2023Pooled it
- Single-nucleus RNA sequencing reveals the cellular composition and the mechanism underlying adrenal myelolipoma.Endocrine · 2026Article
- Screening and identification of key serum biomarkers between PM2.5 and-induced asthma onset.Frontiers in public health · 2025Article
- MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.Clinical epigenetics · 2024Article
- Consistent Multi-Omic Relationships Uncover Molecular Basis of Pediatric Asthma IgE Regulation.medRxiv : the preprint server for health sciences · 2024Article
- The Role of Galectins in Asthma Pathophysiology: A Comprehensive Review.Current issues in molecular biology · 2024Review
- Molecular analysis of duodenal eosinophilia.The Journal of allergy and clinical immunology · 2023Article
- Peripheral blood transcriptomic clusters uncovered immune phenotypes of asthma.Respiratory research · 2022Article
- Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgGThe Journal of allergy and clinical immunology · 2022Article
- Local Immunoglobulin E in nasal polyps: Role and modulation.Frontiers in immunology · 2022Review
- Bioinformatics-based identification of SPNS3 (Spinster homolog 3) as a prognostic biomarker of apoptosis resistance in acute myeloid leukemia.Bioengineered · 2021Article
- The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.ERJ open research · 2021Article
- Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation.Signal transduction and targeted therapy · 2021Article
- Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.JCI insight · 2021Article
- COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum.Journal of cellular and molecular medicine · 2021Article
- Molecular Analysis of IL-5 Receptor Subunit Alpha as a Possible Pharmacogenetic Biomarker in Asthma.Frontiers in medicine · 2020Article
- Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Prognostic significance of Spinster homolog gene family in acute myeloid leukemia.Journal of Cancer · 2020Article
- The nuts and bolts of omics for the clinical allergist.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma.Obesity (Silver Spring, Md.) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAsthma represents a significant public health burden; however, novel biological therapies targeting immunoglobulin E (IgE)-mediated pathways have widened clinical treatment options for the disease.
objectiveIn this study, we sought to identify gene transcripts and gene networks involved in the determination of serum IgE levels in people with asthma that can help inform the development of novel therapeutic agents.
methodsWe analysed gene expression data from a cross-sectional study of 326 Costa Rican children with asthma, aged 6 to 12 years, from the Genetics of Asthma in Costa Rica Study and 610 young adults with asthma, aged 16 to 25 years, from the Childhood Asthma Management Program trial. We utilized differential gene expression analysis and performed weighted gene coexpression network analysis on 25 060 genes, to identify gene transcripts and network modules associated with total IgE, adjusting for age and gender. We used pathway enrichment analyses to identify key biological pathways underlying significant modules. We compared findings that replicated between both populations.
resultsWe identified 31 transcripts associated with total IgE that replicated between the two study cohorts. These results were notable for increased eosinophil-related transcripts (including IL5RA, CLC, SMPD3, CCL23 and CEBPE). Pathway enrichment identified the regulation of T cell tolerance as important in the determination of total IgE levels, supporting a key role for IDO1. CONCLUSIONS AND CLINICAL RELEVANCE: These results provide robust evidence that biologically meaningful gene expression profiles (relating to eosinophilic and regulatory T cell pathways in particular) associated with total IgE levels can be identified in individuals diagnosed with asthma during childhood. These profiles and their constituent genes may represent novel therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.