Evidence map›Paper›PMID 30106994›Full record

ArticlePloS one2018

Oxytocin receptor is regulated by Peg3.

Wesley D Frey, Kaustubh Sharma, Terri L Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wesley D FreyDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.
Kaustubh SharmaDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.
Terri L CainDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.
Katsuhiko NishimoriDepartment of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
Ryoichi TeruyamaDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.
Joomyeong KimDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.ORCID 0000-0001-6577-5526
Louisiana State University · USTohoku University · JP

Funding

Imprinting studies of a paternally expressed Usp29 geneR01GM066225 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI KIM, JOOMYEONG · 2004 to 2013
$2.6M
Aebp2 as an epigenetic regulator for neural crest cellR01GM097074 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KIM, JOOMYEONG · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM066225NIGMS NIH HHS R01 GM097074
6 · The paper itself

Abstract

Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3. In nursing female mice, removal of PEG3 resulted in the increased expression of Oxtr in mammary epithelial cells and also in the hypothalamus. This suggests a repressor role of PEG3 in the expression of Oxtr in these tissues. Overall, this study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process.

Indexed as

Response ElementsAnimalsFemaleGene Expression RegulationHypothalamusKruppel-Like Transcription FactorsLactationMammary Glands, AnimalMiceMice, Mutant StrainsReceptors, OxytocinKruppel-Like Transcription FactorsOXTR protein, mousePeg3 protein, mouseReceptors, Oxytocin

Identifiers

PMID30106994
PMCPMC6091971
OpenAlexW2887557728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.