ArticlePloS one2018
Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effect of dietary anthocyanins on the risk factors related to metabolic syndrome: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Bioactive Compounds and Their Effect on Blood Pressure-A Review.Nutrients · 2020Pooled it
- Preliminary study on the effects of boysenberry juice intake on brown adipose tissue activity in healthy adults.Scientific reports · 2024Trial
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial.The American journal of clinical nutrition · 2023Trial
- Trial
- Edible Berries- An Update on Nutritional Composition and Health Benefits-Part I.Current nutrition reports · 2025Review
- Bioactive Flavonoids in Protecting Against Endothelial Dysfunction and Atherosclerosis.Handbook of experimental pharmacology · 2025Review
- Intra-articular administration of extra-virgin olive oil in degenerative osteoarthritis.Journal of orthopaedic surgery and research · 2024Article
- Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics.Frontiers in genetics · 2024Review
- Innovative applications and therapeutic potential of oilseeds and their by-products: An eco-friendly and sustainable approach.Food science & nutrition · 2023Review
- Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People.Nutrients · 2023Article
- Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of CytochromeAntioxidants & redox signaling · 2023Article
- Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue.iScience · 2022Article
- The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders.International journal of molecular sciences · 2022Review
- Potential Vasculoprotective Effects of Blackcurrant (Molecules (Basel, Switzerland) · 2021Article
- An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations.International journal of molecular sciences · 2021Review
- Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload.Scientific reports · 2021Article
- Plant Polyphenols-Biofortified Foods as a Novel Tool for the Prevention of Human Gut Diseases.Antioxidants (Basel, Switzerland) · 2020Review
- Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.Aging cell · 2020Article
- Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BHBiochemical pharmacology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial cells have an important role in maintaining vascular homeostasis. Age-related disorders (including obesity, diabetes, and hypertension) or aging per se induce endothelial dysfunction that predisposes to the development of atherosclerosis. Polyphenols have been reported to suppress age-related endothelial cell disorders, but their role in vascular function is yet to be determined. We investigated the influence of boysenberry polyphenol on vascular health under metabolic stress in a murine model of dietary obesity. We found that administration of boysenberry polyphenol suppressed production of reactive oxygen species (ROS) and increased production of nitric oxide (NO) in the aorta. It has been reported that p53 induces cellular senescence and has a crucial role in age-related disorders, including heart failure and diabetes. Administration of boysenberry polyphenol significantly reduced the endothelial p53 level in the aorta and ameliorated endothelial cell dysfunction in iliac arteries under metabolic stress. Boysenberry polyphenol also reduced ROS and p53 levels in cultured human umbilical vein endothelial cells (HUVECs), while increasing NO production. Uncoupled endothelial nitric oxide synthase (eNOS monomer) is known to promote ROS production. We found that boysenberry polyphenol reduced eNOS monomer levels both in vivo and in vitro, along with an increase of eNOS dimerization. To investigate the components of boysenberry polyphenol mediating these favorable biological effects, we extracted the anthocyanin fractions. We found that anthocyanins contributed to suppression of ROS and p53, in association with increased NO production and eNOS dimerization. In an ex vivo study, anthocyanins promoted relaxation of iliac arteries from mice with dietary obesity. These findings indicate that boysenberry polyphenol and anthocyanins, a major component of this polyphenol, inhibit endothelial dysfunction and contribute to maintenance of vascular homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.