ArticlePloS one2018
Optimization of total phenolic content from Terminalia chebula Retz. fruits using response surface methodology and evaluation of their antioxidant activities.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Optimized Conditions for the Extraction of Phenolic Compounds fromMolecules (Basel, Switzerland) · 2024Article
- Ultrasound assisted phytochemical extraction of persimmon fruit peel: Integrating ANN modeling and genetic algorithm optimization.Ultrasonics sonochemistry · 2024Article
- Treatment withLife (Basel, Switzerland) · 2023Article
- Chemical Profiling and Therapeutic Evaluation of Standardized Hydroalcoholic Extracts ofMolecules (Basel, Switzerland) · 2023Article
- Impact of Grinding and Sorting Particle Size on Phytochemical Yield inInternational journal of biomaterials · 2023Article
- Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB PathwayMolecules (Basel, Switzerland) · 2022Article
- Review
- Response Surface Methodology Applied to the Optimization of the Preparation of Antioxidant and Antidiabetic Extracts fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Effect of particle size on phytochemical composition and antioxidant properties of Sargassum cristaefolium ethanol extract.Scientific reports · 2021Article
- Response Surface Optimization of Extraction Conditions and In Vitro Antioxidant and Antidiabetic Evaluation of an Under-Valued Medicinal Weed,Plants (Basel, Switzerland) · 2021Article
- Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses.Plants (Basel, Switzerland) · 2020Review
- Effect of Herbal Formulation on Immune Response Enhancement in RAW 264.7 Macrophages.Biomolecules · 2020Article
- Plants of the GenusFrontiers in pharmacology · 2020Review
- The anti-diabetic and antioxidant effects of a combination ofAvicenna journal of phytomedicineArticle
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Authors and funding
4 authors.
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Abstract
Ultrasonic-assisted extraction (UAE), using aqueous ethanol as the solvent, was firstly applied to extract phenolic compounds from Terminalia chebula Retz. fruits (T. chebula fruits). In this study, ethanol concentration (%), ultrasonic intensity (W/cm2), particle diameter (mm), extraction temperature (°C), ultrasonic time (min), liquid-solid ratio (mL/g) and extraction cycle were investigated by single-factor experiment and then optimized using a Box-Behnken design. The optimized result for UAE was 68% ethanol concentration, ultrasonic intensity of 3.6 W/cm2, solid-liquid ratio of 23 mg/mL, particle size of 0.18 mm and ultrasonic time of 20 min for 2 times at 70 °C. The yield of total phenolic was 448.7 ± 2.15 mg GAE/g DW under the above optimum conditions, which agreed with the predicted value (447.8 mg GAE/g DW). Compared to conventional solvent extraction (CSE), UAE extracts showed excellent DPPH radical, DPPH, ABTS scavenging activities and reducing power in a dose-dependent manner, and better than that of CSE extracts. Additionally, the extract of the T. chebula fruits was analyzed by HPLC-ESI/MS. In summary, UAE could effectively extract phenolic compounds from T. chebula fruits. In addition, the extract could be used as a potential source of natural antioxidants.
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