ArticleTransplantation2019
Toward a Sensible Single-antigen Bead Cutoff Based on Kidney Graft Survival.
Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Intragraft donor-specific antibodies reflect histologic heterogeneity in kidney allografts with concurrent serum DSA.Frontiers in immunology · 2026Article
- Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival.World journal of transplantation · 2025Article
- A Prospective Multicenter Luminex-Based Clinical Algorithm to Define Unacceptable HLA Mismatches Before Kidney Transplantation. Consequences on Outcome, Waiting Time, and Wait List Composition.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Circulating Immune Complexes and Complement Activation in Sensitized Kidney Transplant Recipients.International journal of molecular sciences · 2024Article
- Everolimus plus reduced calcineurin inhibitor preventsFrontiers in transplantation · 2023Article
- Principles of Virtual Crossmatch Testing for Kidney Transplantation.Kidney international reports · 2022Review
- BSHI/BTS guidance on crossmatching before deceased donor kidney transplantation.International journal of immunogenetics · 2022Review
- ATG-Fresenius increases the risk of red blood cell transfusion after kidney transplantation.Frontiers in immunology · 2022Observational
- The Accuracy of Sequence-Specific Oligonucleotide and Real-Time Polymerase Chain Reaction HLA Typing in Determining the Presence of Pre-Transplant Donor-Specific Anti-HLA Antibodies and Total Eplet Mismatches for Deceased Donor Kidney Transplantation.Frontiers in immunology · 2022Article
- T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation.Frontiers in immunology · 2021Article
- Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts.Journal of transplantation · 2020Article
- Antibodies against ARHGDIB are associated with long-term kidney graft loss.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Review
- Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
43 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no consensus in the literature on the interpretation of single-antigen bead positive for a specific HLA antibody.
methodsTo inform the debate, we studied the relationship between various single-antigen bead positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants.
resultsFirst, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute median fluorescence intensities (MFIs). Next, we determined pretransplant DSA using various MFI cutoffs, signal-to-background ratios, and combinations thereof. The impact of the various cutoffs was studied by comparing the graft survival between the DSA-positive and DSA-negative groups. We did not observe a strong impact of various cutoff levels on 10-year graft survival. A stronger relationship between the cutoff level and 1-year graft survival for DSA-positive transplants was found when using signal-to-background ratios, most pronounced for the bead of the same HLA locus with lowest MFI taken as background.
conclusionsWith respect to pretransplant risk stratification, we propose a signal-to-background ratio-6 (using the bead of the same HLA-locus with lowest MFI as background) cutoff of 15 combined with an MFI cutoff of 500, resulting in 8% and 21% lower 1- and 10-year graft survivals, respectively, for 8% DSA-positive transplants.
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