ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018
Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- The Influence of the Extracorporeal Membrane Oxygenation Circuit and Components on Anticoagulation Management: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Consensus statement of the Paediatric Anaesthesiology and Intensive Therapy Section of the Polish Society of Anaesthesiology and Intensive Therapy on the use of VV ECMO in paediatric patients for the treatment of acute respiratory failure.Anaesthesiology intensive therapy · 2026Article
- Pediatric Versus Adult Shear-Induced Hemolysis: Are Age-Related Blood Properties the Main Cause for Differences?Artificial organs · 2026Article
- Urinary carbonic anhydrase 1 excretion is a marker of hemolysis-triggering conditions suitable for point-of-care testing.Blood global hematology · 2026Article
- Magnetostaltic pumping in an ex vivo extracorporeal membrane oxygenation model.Journal of translational medicine · 2026Article
- Hemolysis Monitoring Practices during Extracorporeal Membrane Oxygenation: A Survey Report.Blood purification · 2026Article
- Article
- Progress of extracorporeal centrifugal pumps for mechanical circulatory supports.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Article
- Article
- Percutaneous Mechanical Circulatory Support in Acute Heart Failure Complicated with Cardiogenic Shock.Journal of clinical medicine · 2024Review
- Observational
- Hemostasis in neonatal ECMO.Frontiers in pediatrics · 2022Review
- Correlation among Hemolysis Biomarkers in Pediatric Patients Undergoing Extracorporeal Membrane Oxygenation.The journal of extra-corporeal technology · 2021Article
- Nursing effect of ECMO combined with CRRT in the treatment of fulminant myocarditis: A protocol of randomized controlled trial.Medicine · 2021Article
- Editorial: Neonatal ECMO in 2019: Where Are We Now? Where Next?Frontiers in pediatrics · 2021Article
- Surgery in Neonatal and Pediatric ECMO Patients Other Than Congenital Diaphragmatic Hernia Repair: A 10-Year Experience.Frontiers in pediatrics · 2021Article
- Hematologic concerns in extracorporeal membrane oxygenation.Research and practice in thrombosis and haemostasis · 2020Review
- Case Report First-in-Man Method Description: Left Ventricular Unloading With iVAC2L During Veno-Arterial Extracorporeal Membrane Oxygenation: From Veno-Arterial Extracorporeal Membrane Oxygenation to ECMELLA to EC-iVAC®.Frontiers in cardiovascular medicine · 2020Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesTo describe factors associated with hemolysis during pediatric extracorporeal membrane oxygenation and the relationships between hemolysis, complications, and mortality.
designSecondary analysis of data collected prospectively by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014.
settingThree Collaborative Pediatric Critical Care Research Network-affiliated hospitals. PATIENTS: Age less than 19 years and treated with extracorporeal membrane oxygenation.
interventionsNone. MEASUREMENTS AND MAIN
resultsHemolysis was defined based on peak plasma free hemoglobin levels during extracorporeal membrane oxygenation and categorized as none (< 0.001 g/L), mild (0.001 to < 0.5 g/L), moderate (0.5 to < 1.0 g/L), or severe (≥ 1.0 g/L). Of 216 patients, four (1.9%) had no hemolysis, 67 (31.0%) had mild, 51 (23.6%) had moderate, and 94 (43.5%) had severe. On multivariable analysis, variables independently associated with higher daily plasma free hemoglobin concentration included the use of in-line hemofiltration or other continuous renal replacement therapy, higher hemoglobin concentration, higher total bilirubin concentration, lower mean heparin infusion dose, lower body weight, and lower platelet count. Using multivariable Cox modeling, daily plasma free hemoglobin was independently associated with development of renal failure during extracorporeal membrane oxygenation (defined as creatinine > 2 mg/dL [> 176.8 μmol/L] or use of in-line hemofiltration or continuous renal replacement therapy) (hazard ratio, 1.04; 95% CI, 1.02-1.06; p < 0.001), but not mortality (hazard ratio, 1.01; 95% CI, 0.99-1.04; p = 0.389).
conclusionsHemolysis is common during pediatric extracorporeal membrane oxygenation. Hemolysis may contribute to the development of renal failure, and therapies used to manage renal failure such as in-line hemofiltration and other forms of continuous renal replacement therapy may contribute to hemolysis. Hemolysis was not associated with mortality after controlling for other factors. Monitoring for hemolysis should be a routine part of extracorporeal membrane oxygenation practice, and efforts to reduce hemolysis may improve patient care.
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