ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018
Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Risk Factors for Life-Threatening Asthma Attacks and Asthma-Related Mortality in Children-A Systematic Review.Pediatric pulmonology · 2025Pooled it
- Risk Factors Associated With Escalation of Therapy in Hospitalized Children With Asthma.Hospital pediatrics · 2026Article
- Child Opportunity Index and Outcomes of Children Admitted to US PICUs for Critical Asthma.Pediatric pulmonology · 2025Article
- Association between income, employment status, and asthma outcomes: a systematic review and meta-analysis.The Lancet regional health. Europe · 2025Article
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- Evaluation of Asthma Course in Patients Hospitalized in Pediatric Intensive Care Unit Due to Severe Asthma Exacerbation.Medicina (Kaunas, Lithuania) · 2025Article
- Features of children with critical asthma hospitalized in a pediatric intensive care unit: Results from the ICU-3A study.Pediatric pulmonology · 2025Article
- Outcomes of children with life-threatening status asthmaticus requiring isoflurane therapy and extracorporeal life support.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children.The journal of allergy and clinical immunology. Global · 2023Article
- Ethnic variation in asthma healthcare utilisation and exacerbation: systematic review and meta-analysis.ERJ open research · 2023Review
- Initial emergency department vital signs may predict PICU admission in pediatric patients presenting with asthma exacerbation.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Observational
- Changes in the Use of Invasive and Noninvasive Mechanical Ventilation in Pediatric Asthma: 2009-2019.Annals of the American Thoracic Society · 2023Article
- Past asthma exacerbation in children predicting future exacerbation: a systematic review.ERJ open research · 2022Article
- Geospatial Analysis of Social Determinants of Health Identifies Neighborhood Hot Spots Associated With Pediatric Intensive Care Use for Life-Threatening Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City.The Journal of pediatrics · 2020Article
- Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study.ERJ open research · 2020Article
- Factors Associated with Failure of Intermittent Nebulization with Short-Acting Beta-Agonists in Children with Severe Asthma Exacerbation.Journal of asthma and allergy · 2020Article
- Continuous versus intermittent short-acting β2-agonists nebulization as first-line therapy in hospitalized children with severe asthma exacerbation: a propensity score matching analysis.Asthma research and practice · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine risk factors associated with admission to a PICU with or without endotracheal intubation for an asthma exacerbation. We hypothesized that children with critical and near-fatal asthma would have distinguishing clinical features but varying degrees of asthma severity and measures of type 2 inflammation.
designRetrospective analysis of prospectively collected data of children with asthma recruited into outpatient asthma clinical research studies at Emory University between 2004 and 2015.
settingLarge, free-standing academic quaternary care children's hospital in Atlanta, GA. PATIENTS: Children 6-18 years old with physician-diagnosed and confirmed asthma.
interventionsNone. MEASUREMENTS AND MAIN
resultsA total of 579 children were analyzed with 170 children (29.4%) being admitted to the PICU for an asthma exacerbation in their lifetime. Of these 170 children with a history of critical asthma, 24.1% were classified as having mild-to-moderate asthma, and 83 of 170 children (48.8%) had been intubated and experienced near-fatal asthma. Multiple logistic regression was used to identify risk factors associated with increased odds of PICU admission with or without endotracheal intubation. Hospitalization within the prior 12 months of survey (odds ratio, 8.19; 95% CI, 4.83-13.89), a history of pneumonia (odds ratio, 2.56; 95% CI, 1.52-4.29), having a designation of increased chronic asthma severity on high-dose inhaled corticosteroids (odds ratio, 2.76; 95% CI, 1.62-4.70), having a father with asthma (odds ratio, 2.15; 95% CI, 1.23-3.76), living in a region with a higher burden of poverty (odds ratio, 1.28; 95% CI, 1.02-1.61), and being of black race (odds ratio, 2.01; 95% CI, 1.05-3.84) were all associated with increased odds of PICU admission with or without intubation.
conclusionsOur findings suggest that there are factors associated with critical and near-fatal asthma, distinct from the chronic asthma severity designations, that should be the focus of future investigation.
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