Evidence map›Paper›PMID 30106723›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2019

Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts.

Md Murad Hossain, Randal K Detwiler, Emily H Chang, Melissa C Caughey, Melrose W Fisher, Timothy C Nichols, Elizabeth P Merricks, Robin A Raymer, Margaret Whitford, Dwight A Bellinger and 2 more

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Md Murad Hossain
Randal K Detwiler
Emily H Chang
Melissa C Caughey
Melrose W Fisher
Timothy C Nichols
Elizabeth P Merricks
Robin A Raymer
Margaret Whitford
Dwight A Bellinger
Lauren E Wimsey
Caterina M Gallippi
University of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque with High Stroke RiskR01HL092944 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2009 to 2022
$5.5M
VisR Ultrasound for Noninvasively Monitoring Renal Allograft HealthR01DK107740 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Caterina M Gallippi · 2016 to 2026
$5.2M
DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular DystropR01NS074057 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2011 to 2015
$2.0M
NHLBI NIH HHS R01 HL092944NIDDK NIH HHS R01 DK107740NINDS NIH HHS R01 NS074057
6 · The paper itself

Abstract

The kidney is an anisotropic organ, with higher elasticity along versus across nephrons. The degree of mechanical anisotropy in the kidney may be diagnostically relevant if properly exploited; however, if improperly controlled, anisotropy may confound stiffness measurements. The purpose of this study is to demonstrate the clinical feasibility of acoustic radiation force (ARF)-induced peak displacement (PD) measures for both exploiting and obviating mechanical anisotropy in the cortex of human kidney allografts, in vivo. Validation of the imaging methods is provided by preclinical studies in pig kidneys, in which ARF-induced PD values were significantly higher ( , Wilcoxon) when the transducer executing asymmetric ARF was oriented across versus along the nephrons. The ratio of these PD values obtained with the transducer oriented across versus along the nephrons strongly linearly correlated ( R

Indexed as

AllograftsKidney CortexKidney TransplantationAdultAgedAnimalsAnisotropyElasticity Imaging TechniquesElastic ModulusFemaleHumansMaleMiddle AgedRenal Insufficiency, ChronicSwine

Identifiers

PMID30106723
PMCPMC8232042
OpenAlexW2902928764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.