ArticleJBRA assisted reproduction2018
The effects of male age on sperm DNA damage: an evaluation of 2,178 semen samples.
Article in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Fertility in the aging male: a systematic review.Fertility and sterility · 2022Pooled it
- Flow cytometry sperm apoptosis test can predict sperm DNA fragmentation and can be used as an effective and easy-to-perform screening method for males from infertile couples.Translational andrology and urology · 2026Article
- SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis.Nature communications · 2026Article
- The role of sperm DNA fragmentation testing in predicting IVF and PGT-A outcomes.Scientific reports · 2026Article
- Sperm DNA Fragmentation: The Concept and Its Use in Assisted Reproduction.Advances in experimental medicine and biology · 2026Review
- Unraveling the Regulatory Function of MicroRNAs in Reproductive System Apoptosis and Their Implications for Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Early pregnancy loss rate in first-time fresh cycles of low prognosis patients according to the POSEIDON criteria: a single-center data analysis.Reproductive biology and endocrinology : RB&E · 2025Article
- Influence of Bacteriospermia, Host and Lifestyle Factors on Sperm DNA Integrity: A Cross-Sectional Study Based on a Fertility Center of Nepal.Journal of family & reproductive health · 2025Article
- Relationship between male aging and semen quality: a retrospective study on over 2500 men.Archives of gynecology and obstetrics · 2024Article
- Comparative developmental competence ofVeterinary world · 2024Article
- Advanced Paternal Age: A New Indicator for the Use of Microfluidic Devices for Sperm DNA Fragmentation Selection.Journal of clinical medicine · 2024Article
- Performing a sperm DNA fragmentation test in addition to semen examination based on the WHO criteria can be a more accurate diagnosis of IVF outcomes.BMC urology · 2023Article
- Male Clinical Parameters (Age, Stature, Weight, Body Mass Index, Smoking History, Alcohol Consumption) Bear Minimal Relationship to the Level of Sperm DNA Fragmentation.Journal of personalized medicine · 2023Article
- Does advanced paternal age affect global DNA methylation of human spermatozoa and intracytoplasmic sperm injection outcome?Journal of the Turkish German Gynecological Association · 2023Article
- Comparison of zeta potential and physiological intracytoplasmic sperm injection in obtaining sperms with a lower DNA fragmentation index: A cross-sectional study.International journal of reproductive biomedicine · 2022Article
- Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Controlled ovarian hyperstimulation parameters are not associated withFrontiers in endocrinology · 2022Article
- Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review.The world journal of men's health · 2022Article
- Impact of metabolic syndrome on the viability of human spermatozoa: a cross-sectional descriptive study in men from infertile couples.Basic and clinical andrology · 2021Article
- Correlation between sperm DNA fragmentation index and semen parameters in 418 men seen at a fertility center.JBRA assisted reproduction · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the effects of male age on sperm DNA damage.
methodsThis cross-sectional study included semen samples collected from 2,178 men seen at an infertility clinic. For DNA integrity analysis, the proportions of spermatozoa showing DNA fragmentation (TUNEL assay), abnormal chromatin packaging/underprotamination (chromomycin A
resultsAlthough aging did not affect sperm apoptosis (
conclusionSperm DNA fragmentation worsened with age and was apparently associated with mitochondrial damage. The age-related increase in sperm DNA damage suggests that delaying childbearing, not only in women but also in men, might jeopardize a couple's reproductive capacity. The increase seen in chromatin packaging might represent a protective feature for DNA. However, additional studies must be performed to confirm the results concerning chromatin packaging/protamination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.