Evidence map›Paper›PMID 30106394›Full record

ArticleScientific data2018

The REMBRANDT study, a large collection of genomic data from brain cancer patients.

Yuriy Gusev, Krithika Bhuvaneshwar, Lei Song, Jean-Claude Zenklusen, Howard Fine, Subha Madhavan

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 3 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 3 syntheses or guidelines pooled it, 215 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. TCGA-TCIA Impact on Radiogenomics Cancer Research: A Systematic Review.International journal of molecular sciences · 2019
    Pooled it
  4. Article
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  8. Cancers · 2026
    Article
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  17. Review
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  19. Sialylation Inhibition Impairs Migration and Promotes Adhesion of GBM Cells.International journal of molecular sciences · 2025
    Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuriy GusevInnovation Center for Biomedical Informatics (ICBI), Georgetown University Medical Center, Washington DC 20007, USA.ORCID 0000-0001-7371-4715
Krithika BhuvaneshwarInnovation Center for Biomedical Informatics (ICBI), Georgetown University Medical Center, Washington DC 20007, USA.
Lei SongNational Cancer Institute, Rockville, MD, USA.
Jean-Claude ZenklusenNational Cancer Institute, Rockville, MD, USA.
Howard FineNewYork Presbyterian Hospital, New York, NY, USA.
Subha MadhavanInnovation Center for Biomedical Informatics (ICBI), Georgetown University Medical Center, Washington DC 20007, USA.
Georgetown University · USNational Cancer Institute · USNewYork–Presbyterian Hospital · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
NCATS NIH HHS UL1 TR001409NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

The Rembrandt brain cancer dataset includes 671 patients collected from 14 contributing institutions from 2004-2006. It is accessible for conducting clinical translational research using the open access Georgetown Database of Cancer (G-DOC) platform. In addition, the raw and processed genomics and transcriptomics data have also been made available via the public NCBI GEO repository as a super series GSE108476. Such combined datasets would provide researchers with a unique opportunity to conduct integrative analysis of gene expression and copy number changes in patients alongside clinical outcomes (overall survival) using this large brain cancer study.

Indexed as

Databases, GeneticBrain NeoplasmsDNA, NeoplasmGene Expression Regulation, NeoplasticGenomicsHumansDNA, Neoplasm

Identifiers

PMID30106394
PMCPMC6091243
OpenAlexW2887513492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.