ArticleeLife2018
Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- HDAC1/2-mediated repression of Wnt receptor expression orients asymmetric division polarity in Caenorhabditis elegans.Development (Cambridge, England) · 2026Article
- Genome-Wide Identification and Characterization of theBiology · 2026Article
- Mutual inhibition model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation.PLoS computational biology · 2026Article
- Specialized high-capacity mitochondria fuel cell invasion.Current biology : CB · 2026Article
- Polarized SOS activity orchestrates FGF-directed cell migration in vivo.Current biology : CB · 2026Article
- Regulation of hlh-2 transcription during specification of the anchor cell of the C. elegans hermaphrodite gonad.G3 (Bethesda, Md.) · 2026Article
- Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation.PloS one · 2026Article
- Matrix metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution.Molecular biology of the cell · 2025Article
- Cooperative short- and long-range interactions enable robust symmetry breaking and axis formation.bioRxiv : the preprint server for biology · 2025Article
- FGF diffusion is required for directed migration of postembryonic muscle progenitors in C. elegans.Development (Cambridge, England) · 2025Article
- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans.PLoS genetics · 2025Article
- Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A collagen IV fluorophore knock-in toolkit reveals trimer diversity in C. elegans basement membranes.The Journal of cell biology · 2025Article
- EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.Development (Cambridge, England) · 2025Article
- MIG-21 is a novel regulator of Wnt and Netrin signaling in gonad migration identified from published scRNA-seq data and functionally validated inbioRxiv : the preprint server for biology · 2025Article
- Morphogens and Cell-Derived Structures (Exosomes and Cytonemes) as Components of the Communication Between Cells.International journal of molecular sciences · 2025Review
- Live imaging of paracrine signaling: Advances in visualization and tracking techniques.Cell structure and function · 2025Review
- Identification of the Wnt signal peptide that directs secretion on extracellular vesicles.Science advances · 2024Article
- Synthetically programming natural cell-cell communication pathways for tissue engineering.Current opinion in biomedical engineering · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Wnts are evolutionarily conserved signaling proteins with essential roles in development and disease that have often been thought to spread between cells and signal at a distance. However, recent studies have challenged this model, and whether long-distance extracellular Wnt dispersal occurs and is biologically relevant is debated. Understanding fundamental aspects of Wnt dispersal has been limited by challenges with observing endogenous ligands in vivo, which has prevented directly testing hypotheses. Here, we have generated functional, fluorescently tagged alleles for a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.