ArticleeLife2018
The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.
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Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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96citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
96 citing papers in PubMed, 136 citations in OpenAlex.
- Monte Carlo modeling of the formation and organization of ion channel clustering.PLoS computational biology · 2026Article
- Heterozygous Loss of Scn1b Results in Concealed Conduction Phenotype Unmasked by Osmotic Stress.bioRxiv : the preprint server for biology · 2026Article
- Cardiac Impulse Propagation: An Integrated View.JACC. Basic to translational science · 2026Review
- Phospho-mimic βIII-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice.Journal of molecular and cellular cardiology · 2026Article
- Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.JACC. Clinical electrophysiology · 2026Review
- Common genetic variants of the cardiac sodium channel alter patient response to class 1b antiarrhythmics.Journal of precision medicine (Amsterdam, Netherlands) · 2026Article
- Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels.Nature communications · 2026Article
- Selectivity Filter Mutation in NaJACC. Clinical electrophysiology · 2026Article
- Article
- Ephaptic coupling and the source-sink effect of cardiac conduction.The Journal of physiology · 2026Article
- Dissecting Gap Junctional and Ephaptic Contributions to Electrical Conduction in a Novel Cardiomyocyte Pair Model.bioRxiv : the preprint server for biology · 2026Article
- Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives.The Journal of physiology · 2026Review
- Ultrastructural Analysis of In Vitro Glycated Engineered Skin.Journal of cosmetic dermatology · 2026Article
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- Common Genetic Variants of The Cardiac Sodium Channel Alter Patient Response to Class 1b Antiarrhythmics.bioRxiv : the preprint server for biology · 2026Article
- The influence of intercalated disk nanostructure on local ionic currents and cardiac conduction.Biophysical journal · 2026Article
- Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3.bioRxiv : the preprint server for biology · 2025Article
- Analytical Insights into Ephaptic Coupling and Its Effect on Conduction Velocity.Journal of mathematical biology · 2025Article
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- SARS-CoV-2 spike protein-induced inflammation underlies proarrhythmia in COVID-19.Scientific reports · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Rengasayee VeeraraghavanVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.ORCID https://orcid.org/0000-0002-8364-2222
Gregory S HoekerVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Anita Alvarez-LaviadaDepartment of Myocardial Function, Imperial College London, London, United Kingdom.
Daniel HoaglandVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Xiaoping WanHeart and Vascular Research Center, MetroHealth Medical Center, Department of Medicine, Case Western Reserve University, Cleveland, United States.
D Ryan KingVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Jose Sanchez-AlonsoDepartment of Myocardial Function, Imperial College London, London, United Kingdom.
Chunling ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.
Jane JourdanVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Lori L IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.
Isabelle DeschenesHeart and Vascular Research Center, MetroHealth Medical Center, Department of Medicine, Case Western Reserve University, Cleveland, United States.
James W SmythVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Julia GorelikDepartment of Myocardial Function, Imperial College London, London, United Kingdom.
Steven PoelzingVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.
Robert G GourdieVirginia Tech Carilion Research Institute, Virginia Polytechnic University, Roanoke, United States.ORCID http://orcid.org/0000-0001-6021-0796
Virginia Tech · USImperial College London · GBMetroHealth Medical Center · USUniversity of Michigan · US
Funding
PATTERNING OF GAP JUNCTION COUPLING IN DEVELOPING HEARTR01HL056728 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G · 1997 to 2021
$5.6MRole of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8MRole of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9MSignaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6MTranslation initiation in cardiac intercellular communication and stress-induced remodelingR01HL132236 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SMYTH, JAMES WILLIAM · 2017 to 2021
$2.0MThe Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8MAmerican Heart Association 16SDG29870007British Heart Foundation RG/17/13/33173NHLBI NIH HHS R01 HL056728NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL102298-01A1NHLBI NIH HHS R01 HL132236NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855NHLBI NIH HHS RO1 HL56728-15A2NHLBI NIH HHS RO1 HL HL141855-01NIH HHS R01 HL102298-01A1NIH HHS R37NS076752NINDS NIH HHS R37 NS076752
Abstract
Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) -mediated adhesion scaffolds
Indexed as
Action PotentialsAnimalsArrhythmias, CardiacCell AdhesionCell CommunicationComputational BiologyElectric ImpedanceGap JunctionsGuinea PigsHumansMiceModels, CardiovascularMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesPeptidesNAV1.5 Voltage-Gated Sodium ChannelPeptidesScn1b protein, mouseScn5a protein, mouseSodiumVoltage-Gated Sodium Channel beta-1 Subunitapahptic couplingarrhythmiacardiac conductioncell biologygap junctionsguinea pig
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.