Evidence map›Paper›PMID 30106371›Full record

ArticleeLife2018

Functional gradients of the cerebellum.

Xavier Guell, Jeremy D Schmahmann, John DE Gabrieli, Satrajit S Ghosh

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 281 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Trial
  6. Review
  7. Article
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  13. Article
  14. The Cerebellar Connectome.Cerebellum (London, England) · 2026
    Article
  15. The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
    Review

221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xavier GuellMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-0684-0954
Jeremy D SchmahmannLaboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
John DE GabrieliMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Satrajit S GhoshMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-5312-6729

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Resource DiscoveryP41EB019936 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI David Nelson Kennedy · 2016 to 2026
$15.2M
Nipype: Dataflows for Reproducible Biomedical ResearchR01EB020740 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GHOSH, SATRAJIT SUJIT · 2016 to 2019
$2.7M
NIBIB NIH HHS P41 EB019936NIBIB NIH HHS R01 EB020740NIH HHS P41 EB019936NIH HHS R01 EB020740NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation.

Indexed as

AdultBrain MappingCerebellumCerebral CortexCognitionConnectomeFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwayscerebellumfMRIfunctional organizationfunctional topographygradientshumanneuroscienceresting-state

Identifiers

PMID30106371
PMCPMC6092123

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.