ArticleNeuropsychopharmacology reports2018
Bidirectional brain-gut interactions: Involvement of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis.
Article in Neuropsychopharmacology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
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- Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies.Journal of neuroinflammation · 2024Review
- Gut-Brain Crosstalk and the Central Mechanisms of Orofacial Pain.Brain sciences · 2023Review
- Role of social media use in onset of functional gastrointestinal disorders in children.Clinical and experimental pediatrics · 2023Article
- Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice.Scientific reports · 2021Article
- Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.Digestive diseases and sciences · 2019Article
- Exposure to hot and cold environments increases noradrenaline release in the bed nucleus of the stria terminalis in rats.Neuropsychopharmacology reports · 2018Article
- Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain-intestine interactions.Neuropsychopharmacology reports · 2018Article
- Bidirectional brain-gut interactions: Involvement of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis.Neuropsychopharmacology reports · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough the important roles of bidirectional interactions between the brain and gut in stress and emotional responses have long been recognized, the underlying neuronal mechanisms remain unclear. The bed nucleus of the stria terminalis (BNST) is a limbic structure involved in stress responses and negative affective states, such as anxiety and depression. We have previously demonstrated that noradrenergic transmission within the ventral part of the BNST (vBNST) plays a crucial role in anxiety-like behaviors and pain-induced aversion.
objectivesThis study aimed to examine the involvement of noradrenergic transmission via β-adrenoceptors within the vBNST in bidirectional brain-gut interactions.
methodsWe measured the gastric distention (GD)-induced noradrenaline release within the vBNST of freely moving rats using an in vivo microdialysis technique. Gastric emptying and intestinal transit were examined following intra-vBNST injections of isoproterenol, a β-adrenoceptor agonist, in the absence or presence of the coadministration of timolol, a β-adrenoceptor antagonist.
resultsGastric distention at a higher pressure (45 mm Hg) but not at a lower pressure (25 mm Hg) resulted in a significant increase in extracellular noradrenaline levels within the vBNST. Intra-vBNST injections of isoproterenol (30 nmol/side) induced significant reductions in gastric emptying and small intestinal transit, both of which were reversed by the coadministration of timolol (30 nmol/side).
conclusionNoradrenergic transmission via β-adrenoceptors within the vBNST was involved in bidirectional brain-gut interactions. These findings suggest that gastric dysfunction may induce negative affective states via the enhanced release of noradrenaline within the vBNST which, in turn, may cause gastrointestinal impairments.
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