ArticleBrain and behavior2018
Nest-building activity as a reproducible and long-term stroke deficit test in a mouse model of stroke.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
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- An irradiation-free platform for localized skull bone marrow manipulation to dissect the skull-brain axis.Journal of neuroinflammation · 2026Article
- Non-maternal nest building behaviours in mice predict bilateral dorsal hippocampal lesion extent.Behavioural brain research · 2025Article
- Activation of GPER-1 Attenuates Traumatic Brain Injury-Induced Neurological Impairments in Mice.Molecular neurobiology · 2024Article
- Mouse Model of Parkinson's Disease with Bilateral Dorsal Striatum Lesion with 6-Hydroxydopamine Exhibits Cognitive Apathy-like Behavior.International journal of molecular sciences · 2024Article
- Assessment of quality of life and wellbeing in mouse preclinical research - A scoping review.Neuroscience applied · 2024Review
- Bedside to bench: the outlook for psychedelic research.Frontiers in pharmacology · 2023Review
- Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis.Brain, behavior, and immunity · 2023Article
- A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies.Current neuropharmacology · 2022Review
- Interruption of endolysosomal trafficking leads to stroke brain injury.Experimental neurology · 2021Article
- Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model.Environmental research · 2020Article
- Benefits of non-invasive methods compared to telemetry for distress analysis in a murine model of pancreatic cancer.Journal of advanced research · 2020Article
- Tell-tale TINT: Does the Time to Incorporate into Nest Test Evaluate Postsurgical Pain or Welfare in Mice?Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Optimizing functional outcome endpoints for stroke recovery studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Nest-building activity as a reproducible and long-term stroke deficit test in a mouse model of stroke.Brain and behavior · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionNeuroprotective therapeutics achieved from animal studies have not been able to translate into clinical stroke therapies. A major reason may be that the functional tests and outcomes between animal stroke studies and clinical trials are significantly different. Ultimately, functional recovery is most important for stroke patients, but it remains challenging to identify animal functional tests that reflect human stroke deficits. This study aimed to explore whether the nest-building activity can be used as a functional test of mouse stroke deficit.
methodsForty-one C57B6 male mice were randomly assigned into a sham-operated control group and 20-, 40- and 60-min middle cerebral artery occlusion (MCAO) groups. Mice were perfusion-fixed at 21 days following sham surgery or MCAO. Infarct volumes were assessed under the light microscopy. The nest-building activity was characterized and quantitatively evaluated.
resultsThe results show that only a small portion of striatum was damaged after 20-min MCAO. The brain damage areas were expanded from striatum to the neocortex and hippocampus proportionally after 40-min and 60-min MCAO, respectively. Consistently, relative to that of the sham-operated mice, the nest-building activity was insignificantly altered after 20-min MCAO, but dramatically and significantly reduced proportionally following 40-min and 60-min MCAO, respectively. The nest-building deficit was a long-lasting event and could be seen for as long as 14-21 days of recovery, the longest endpoint of this study.
conclusionsThe results suggest that the nest-building activity may be a novel, objective, easy to use, highly sensitive, and long-lasting test that may reflect the multifaceted sensorimotor and cognitive deficits after stroke in humans. Our findings may provide a novel multifaceted test for bridging the gap between animal stroke studies and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.