Evidence map›Paper›PMID 30106245›Full record

ArticleBrain and behavior2018

Genetic influences on prefrontal activation during a verbal fluency task in children: A twin study using near-infrared spectroscopy.

Eisuke Sakakibara, Ryu Takizawa, Yuki Kawakubo, Hitoshi Kuwabara, Toshiaki Kono, Kasumi Hamada, Shiho Okuhata, Satoshi Eguchi, Ayaka Ishii-Takahashi, Kiyoto Kasai

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Eisuke SakakibaraDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-6392-8450
Ryu TakizawaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuki KawakuboDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Hitoshi KuwabaraResearch Center for Child Mental Development, Hamamatsu University School of Medicine, Shizuoka, Japan.
Toshiaki KonoDepartment of Forensic Psychiatry, National Center of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kasumi HamadaThe Department of Social Childhood Care and Education, The Faculty of Health and Welfare, Nayoro City University, Hokkaido, Japan.
Shiho OkuhataDepartment of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Satoshi EguchiDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Ayaka Ishii-TakahashiDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe genetic and environmental influences on prefrontal function in childhood are underinvestigated due to the difficulty of measuring prefrontal function in young subjects, for which near-infrared spectroscopy (NIRS) is a suitable functional neuroimaging technique that facilitates the easy and noninvasive measurement of blood oxygenation in the superficial cerebral cortices.

methodUsing a two-channel NIRS arrangement, we measured changes in bilateral prefrontal blood oxygenation during a category version of the verbal fluency task (VFT) in 27 monozygotic twin pairs and 12 same-sex dizygotic twin pairs ages 5-17 years. We also assessed the participant's full-scale intelligence quotient (FIQ) and retrieved parental socioeconomic status (SES). Classical structured equation modeling was used to estimate the heritability.

resultsThe heritability of VFT-related brain activation was estimated to be 44% and 37% in the right and left prefrontal regions, respectively. We also identified a significant genetic contribution (74%) to FIQ, but did not to VFT task performance. Parental SES was not correlated with FIQ, task performance, or task-related prefrontal activation.

conclusionsThis finding provides further evidence that variance in prefrontal function has a genetic component since childhood and highlights brain function, as measured by NIRS, as a promising candidate for endophenotyping neurodevelopmental disorders.

Indexed as

Intelligence TestsPrefrontal CortexTask Performance and AnalysisAdolescentChildChild, PreschoolEnvironmentExecutive FunctionFemaleFunctional NeuroimagingHumansJapanMaleOxygen ConsumptionOxyhemoglobinsSocial ClassOxyhemoglobinschildrenheritabilitynear‐infrared spectroscopyprefrontal functiontwin studyverbal fluency task

Identifiers

PMID30106245
PMCPMC5991600

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