Evidence map›Paper›PMID 30106232›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival.

Ines Llaudo, Miguel Fribourg, M Edward Medof, Patricia Conde, Jordi Ochando, Peter S Heeger

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  14. Complement and Cancer-A Dysfunctional Relationship?Antibodies (Basel, Switzerland) · 2020
    Review
  15. Review
  16. Review
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  18. Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  19. Role of Complement Activation in Allograft Inflammation.Current transplantation reports · 2019
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ines LlaudoTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miguel FribourgTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Edward MedofInstitute of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Patricia CondeDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jordi OchandoDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter S HeegerTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USCase Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Project I: Immunity to Influenza in Primary Lung Epithelial CellsU19AI117873 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAYOT, FERNAND · 2015 to 2019
$8.6M
Complement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3M
Optimizing mesenchymal stem cell and Treg immunosuppression for controlling SLER01AR067182 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 2015 to 2019
$1.7M
NEI NIH HHS P30 EY011373NIAID NIH HHS R01 AI071185NIAID NIH HHS U19 AI117873NIAMS NIH HHS R01 AR067182
6 · The paper itself

Abstract

Costimulatory blockade-induced murine cardiac allograft survival requires intragraft accumulation of CD11b

Indexed as

Cell MovementGraft SurvivalAbataceptAllograftsAnimalsCTLA-4 AntigenGraft RejectionHeart DiseasesHeart TransplantationHistocompatibility Antigens Class IMiceMice, Inbred BALB CMice, Inbred C57BLMinor Histocompatibility AntigensMyeloid-Derived Suppressor CellsReceptor, Anaphylatoxin C5aAbataceptC5ar1 protein, mouseCTLA-4 AntigenCtla4 protein, mouseHistocompatibility Antigens Class IMinor Histocompatibility AntigensMr1 protein, mouseReceptor, Anaphylatoxin C5aanimal models: murinebasic (laboratory) research/scienceimmunobiologyimmunosuppression/immune modulationmacrophage/monocyte biologymacrophage/monocyte biology: traffickingtolerance: experimental

Identifiers

PMID30106232
PMCPMC6375810
OpenAlexW2886744981

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.