ArticleBrain and behavior2018
The behavioral study on the interactive aggravation between pruritus and depression.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- European S2k Guideline on Chronic PruritusActa dermato-venereologica · 2025Guideline
- The effectiveness of sertraline in alleviating uremic pruritus in hemodialysis patients: a randomized clinical trial.BMC nephrology · 2023Trial
- Breaking the vicious cycle: a bibliometric and visual analysis of the bidirectional relationship between pruritus and negative emotions.Frontiers in psychiatry · 2026Review
- Article
- Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions.Experimental brain research · 2025Article
- A Narrative Review on Stress and Itch: What We Know and What We Would Like to Know.Journal of clinical medicine · 2024Review
- The impact of stress on the behavior of C57BL/6 mice with liver injury: a comparative study.Frontiers in behavioral neuroscience · 2024Article
- Article
- Association of Atopic Dermatitis with Depression and Suicide: A Two-Sample Mendelian Randomization Study.BioMed research international · 2022Article
- Use of Sertraline in Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2021Review
- Review
- Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.Behavioural brain research · 2020Review
- Rodent ketamine depression-related research: Finding patterns in a literature of variability.Behavioural brain research · 2019Review
- Why does stress aggravate itch? A possible role of the amygdala.Experimental dermatology · 2019Article
- Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.Science signaling · 2019Article
- The behavioral study on the interactive aggravation between pruritus and depression.Brain and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe interactive aggravation of pruritus and depression is well-known, but an appropriate experimental model that could mimic this behavioral phenomenon is still lacking. Thus, a systematic animal behavioral investigation was carried out in this study. This will promote the research and treatment of pruritus and depression.
methodsThe 2,4-dinitrofluorobenzene (DNFB)-induced chronic itch model was established to measure the depression index by forced swimming test (FST), tail suspension test (TST), and splash test (ST). The chronic unpredicted mild stress (CUMS)-induced depression model was established to measure spontaneous itch and acute histamine or chloroquine-induced itch behaviors. A depression and itch combining model was also established to measure the scratching and depression behaviors. The motor function of DNFB mice was analyzed by the rotarod test.
resultsThe scratching number, the immobility time in the FST and TST, and the grooming number in the ST test were all significantly increased in the chronic itch model. Mice receiving CUMS treatment showed significantly increased spontaneous scratching number, immobility time in the FST and TST tests, and grooming number in the ST. The combined model showed increased immobility time in FST and TST tests and increased grooming number in ST comparing to the depression model, and showed increased scratching number comparing to the chronic itch model. After histamine (His) or chloroquine (CQ) injection, the scratching numbers of CUMS mice were all significantly increased compared to those of His- and CQ-control, respectively. Anti-depression drug ketamine could significantly inhibit the depression-like behaviors of CUMS mice, and simultaneously stopped the promoting effect on His-induced acute itch.
conclusionsThis study established an appropriate cross aggravation experimental mode and demonstrated that there is cross aggravation between pruritus and depression. The illumination of related mechanisms underlying this cross aggravation effect will provide theoretical basis for the prevention and treatment of depression and pruritus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.