Evidence map›Paper›PMID 30106084›Full record

ArticleInternational journal of molecular medicine2018

Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration.

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weiheng WangDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Xiaodong HuangDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Wenbo LinDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Yuanyuan QiuDepartment of Respiration, Shanghai Electric Power Hospital, Shanghai 200050, P.R. China.
Yunfei HeDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Jiangming YuDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Yanhai XiDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Xiaojian YeDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Second Military Medical University · CNShanghai Electric (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique hypoxic inflammatory microenvironment observed in the spinal cord following spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal stem cells (BMSCs). The aim of the present study was to determine whether hypoxic preconditioning (HP) increased the therapeutic effects of BMSC on SCI. BMSCs were pretreated with cobalt chloride (CoCl2) in vitro, and the proliferative apoptotic and migratory abilities of these hypoxic BMSCs (H‑BMSCs) were assessed. BMSCs and H‑BMSCs derived from green fluorescent protein (GFP) rats were transplanted into SCI rats in vivo. The neurological function, histopathology, inflammation, and number and migration of transplanted cells were examined. HP significantly enhanced BMSC migration (increased hypoxia inducible factor 1α and C‑X‑C motif chemokine receptor 4 expression) and tolerance to apoptotic conditions (decreased caspase‑3 and increased B‑cell lymphoma 2 expression) in vitro. In vivo, H‑BMSC transplantation significantly improved neurological function, decreased spinal cord damage and suppressed the inflammatory response associated with microglial activation. The number of GFP‑positive cells in the SCI core and peripheral region of H‑BMSC animals was increased compared with that in those of BMSC animals, suggesting that HP may increase the survival and migratory abilities of BMSCs and highlights their therapeutic potential for SCI.

Indexed as

AnimalsCaspase 3Cell- and Tissue-Based TherapyCell DifferentiationCell MovementCell SurvivalEnzyme-Linked Immunosorbent AssayFemaleGreen Fluorescent ProteinsInterleukin-1betaInterleukin-6Lymphoma, B-CellMesenchymal Stem CellsRatsSpinal Cord InjuriesCaspase 3Green Fluorescent ProteinsInterleukin-1betaInterleukin-6

Identifiers

PMID30106084
PMCPMC6192716
OpenAlexW2885968542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.