Evidence map›Paper›PMID 30106059›Full record

ArticleNeural regeneration research2018

Novel conductive polypyrrole/silk fibroin scaffold for neural tissue repair.

Ya-Hong Zhao, Chang-Mei Niu, Jia-Qi Shi, Ying-Yu Wang, Yu-Min Yang, Hong-Bo Wang

Abstract read
In one paragraph

Article in Neural regeneration research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. 3D Bioprinting of Neural Tissues.Advanced healthcare materials · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ya-Hong ZhaoKey Laboratory of Science and Technology of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi; Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Chang-Mei NiuMedical School, Nantong University, Nantong, Jiangsu Province, China.
Jia-Qi ShiMedical School, Nantong University, Nantong, Jiangsu Province, China.
Ying-Yu WangWen Zheng College, Soochow University, Suzhou, Jiangsu Province, China.
Yu-Min YangKey Laboratory of Science and Technology of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi; Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Hong-Bo WangKey Laboratory of Science and Technology of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three dimensional (3D) bioprinting, which involves depositing bioinks (mixed biomaterials) layer by layer to form computer-aided designs, is an ideal method for fabricating complex 3D biological structures. However, it remains challenging to prepare biomaterials with micro-nanostructures that accurately mimic the nanostructural features of natural tissues. A novel nanotechnological tool, electrospinning, permits the processing and modification of proper nanoscale biomaterials to enhance neural cell adhesion, migration, proliferation, differentiation, and subsequent nerve regeneration. The composite scaffold was prepared by combining 3D bioprinting with subsequent electrochemical deposition of polypyrrole and electrospinning of silk fibroin to form a composite polypyrrole/silk fibroin scaffold. Fourier transform infrared spectroscopy was used to analyze scaffold composition. The surface morphology of the scaffold was observed by light microscopy and scanning electron microscopy. A digital multimeter was used to measure the resistivity of prepared scaffolds. Light microscopy was applied to observe the surface morphology of scaffolds immersed in water or Dulbecco's Modified Eagle's Medium at 37°C for 30 days to assess stability. Results showed characteristic peaks of polypyrrole and silk fibroin in the synthesized conductive polypyrrole/silk fibroin scaffold, as well as the structure of the electrospun nanofiber layer on the surface. The electrical conductivity was 1 × 10

Indexed as

biocompatibilitycomposite nanofiberconductivityelectrospinningL929 cellsnerve regenerationnerve repairneural regenerationpolypyrrolescaffoldSchwann cellssilk fibrointhree dimensional bioprinting

Identifiers

PMID30106059
PMCPMC6108196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.