Evidence map›Paper›PMID 30105967›Full record

Trial reportThe American journal of tropical medicine and hygiene2018

Molecular Detection of Residual Parasitemia after Pyronaridine-Artesunate or Artemether-Lumefantrine Treatment of Uncomplicated

Johanna M Roth, Patrick Sawa, George Omweri, Nicodemus Makio, Victor Osoti, Menno D de Jong, Henk D F H Schallig, Pètra F Mens

Open access · bronzeAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  3. Trial
  4. Trial
  5. Detection of novelFrontiers in cellular and infection microbiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Detection ofThe American journal of tropical medicine and hygiene · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Johanna M RothDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Patrick SawaHuman Health Division, International Centre of Insect Physiology and Ecology, Mbita Point, Kenya.
George OmweriHuman Health Division, International Centre of Insect Physiology and Ecology, Mbita Point, Kenya.
Nicodemus MakioHuman Health Division, International Centre of Insect Physiology and Ecology, Mbita Point, Kenya.
Victor OsotiHuman Health Division, International Centre of Insect Physiology and Ecology, Mbita Point, Kenya.
Menno D de JongDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Henk D F H SchalligDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Pètra F MensDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Academic Medical Center · NLInternational Centre of Insect Physiology and Ecology · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin resistance is rapidly rising in Southeast Asia and may spread to African countries, where efficacy estimates are currently still excellent. Extensive monitoring of parasite clearance dynamics after treatment is needed to determine whether responsiveness to artemisinin-based combination therapies (ACT) is changing in Africa. In this study, Kenyan children with uncomplicated

Indexed as

AntimalarialsArtemether, Lumefantrine Drug CombinationArtesunateMalaria, FalciparumNaphthyridinesParasitemiaAntigens, ProtozoanChildChild, PreschoolDNA, ProtozoanDrug CombinationsDrug ResistanceFemaleHumansImmunoassayInfantAntigens, ProtozoanAntimalarialsArtemether, Lumefantrine Drug CombinationArtesunateDNA, ProtozoanDrug CombinationsNaphthyridinespyronaridine

Identifiers

PMID30105967
PMCPMC6159604
OpenAlexW2887538071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.