Evidence map›Paper›PMID 30105929›Full record

ArticleTranscription2018

Poor codon optimality as a signal to degrade transcripts with frameshifts.

Miquel Àngel Schikora-Tamarit, Lucas B Carey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transcription, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Ribosome Profiling for Novel Antigen Discovery.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miquel Àngel Schikora-Tamarita Systems Bioengineering Program, Department of Experimental and Health Sciences , Universitat Pompeu Fabra , Barcelona , Spain.ORCID 0000-0003-2964-9818
Lucas B Careya Systems Bioengineering Program, Department of Experimental and Health Sciences , Universitat Pompeu Fabra , Barcelona , Spain.ORCID 0000-0002-7245-6379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.

Indexed as

Base SequenceCodonCodon, NonsenseGene ExpressionNonsense Mediated mRNA DecayOpen Reading FramesRNA, MessengerRNA PrecursorsRNA, TransferSaccharomyces cerevisiaeSequence DeletionTranscriptomeWhole Genome SequencingCodonCodon, NonsenseRNA, MessengerRNA PrecursorsRNA, Transfercodon biasframeshiftsmRNA qualityNonsense-mediated decaytranslation

Identifiers

PMID30105929
PMCPMC6150615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.