ArticleJournal of clinical laboratory analysis2019
Association of neutrophil-to-lymphocyte ratio and natural killer cell activity revealed by measurement of interferon-gamma levels in a healthy population.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Altered NK cell receptor profiles and immune-inflammatory markers in adolescent major depressive disorder: associations with cognitive impairment.BMC psychiatry · 2026Article
- What affects natural killer cell activity: a cross-sectional study.Frontiers in immunology · 2026Article
- Association Between Complete Blood Cell Count (CBC)-Derived Inflammatory Markers and Natural Killer Cell Activity: A Cross-Sectional Study.Journal of inflammation research · 2026Article
- Eosinophilic Dermatoses: Cause of Non-Infectious Erythema after Volume Replacement with Diced Acellular Dermal Matrix in Breast Cancer?Life (Basel, Switzerland) · 2024Article
- Interferon-Gamma Secretion Is Significantly Decreased in Stage III Breast Cancer Patients.International journal of molecular sciences · 2024Article
- Safety and efficacy of SNK01 (autologous natural killer cells) in combination with cytotoxic chemotherapy and/or cetuximab after failure of prior tyrosine kinase inhibitor in non-small cell lung cancer: non-clinical mouse model and phase I/IIa clinical study.Journal for immunotherapy of cancer · 2024Article
- Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms-a Danish longitudinal study.Blood cancer journal · 2024Article
- Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis.PLoS neglected tropical diseases · 2023Article
- Article
- Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity.Diagnostics (Basel, Switzerland) · 2022Article
- Natural Killer Cells as a Potential Biomarker for Predicting Immunotherapy Efficacy in Patients with Non-Small Cell Lung Cancer.Targeted oncology · 2020Article
- Article
- A Flow Cytometry-Based Whole Blood Natural Killer Cell Cytotoxicity Assay Using Overnight Cytokine Activation.Frontiers in immunology · 2020Article
- Natural killer cell activity and prostate cancer risk in veteran men undergoing prostate biopsy.Cancer epidemiology · 2019Article
- Association of neutrophil-to-lymphocyte ratio and natural killer cell activity revealed by measurement of interferon-gamma levels in a healthy population.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile a method of assaying natural killer (NK) cell activity by measuring the amount of interferon (IFN)-γ released from NK cells has been proposed, no data are available about the factors that influence IFN-γ levels related to NK cell activity. NLR has recently been reported to be a predictor of several diseases. In the present study, we investigated the pre-analytical variables for NK cell activity using measurements of IFN-γ and the relationship between NLR and NK cell activity.
methodsThe NK cell activity was assessed with the measurement of IFN-γ after stimulation with an NK cell-specific stimulant (NK Vue
resultNatural killer cell activity varied widely (range, 44.2-1775.6 pg/mL). NK cell activity was higher in females than in males (P = 0.014). NK cell activity decreased with increasing NLR (P = 0.004, r = -0.32) but NK cell activity showed no significant association with NK cell count or other lymphocyte subpopulations. NK cell activity levels according to CRP quartile were significantly different (P = 0.025).
conclusionWe have observed that NK cell activity when assessed by IFN-γ level measurement was negatively correlating with NLR. This result can be helpful in interpreting or predicting NK cell activity in the clinical environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.