Evidence map›Paper›PMID 30105788›Full record

ArticleActa ophthalmologica2018

Protruded retinal layers within the optic nerve head neuroretinal rim.

Lucas A Torres, Jayme R Vianna, Faisal Jarrar, Glen P Sharpe, Makoto Araie, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Masanori Hangai, Aiko Iwase and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lucas A TorresDepartment of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID http://orcid.org/0000-0003-4136-7362
Jayme R ViannaDepartment of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Faisal JarrarDepartment of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Glen P SharpeDepartment of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Makoto AraieKanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
Joseph CaprioliDepartment of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.
Shaban DemirelDevers Eye Institute, Legacy Research Institute, Portland, Oregon, USA.
Christopher A GirkinDepartment of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Masanori HangaiDepartment of Ophthalmology, Saitama Medical School, Moro, Japan.
Aiko IwaseTajimi Iwase Eye Clinic, Tajimi, Japan.
Jeffrey M LiebmannNew York Eye and Ear Infirmary, New York University School of Medicine, New York, New York, USA.
Christian Y MardinDepartment of Ophthalmology, University of Erlangen, Erlangen, Germany.
Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Tohoku, Japan.ORCID http://orcid.org/0000-0002-5591-4155
Harry A QuigleyWilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Alexander F ScheuerleDepartment of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Kazuhisa SugiyamaDepartment of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Hidenobu TaniharaDepartment of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Goji TomitaDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.
Yasuo YanagiDepartment of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Claude F BurgoyneDevers Eye Institute, Legacy Research Institute, Portland, Oregon, USA.
Balwantray C ChauhanDepartment of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID http://orcid.org/0000-0002-7936-6907

Funding

Optic Nerve Head SDOCT Imaging in GlaucomaR01EY021281 · NEI · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI BURGOYNE, CLAUDE F · 2011 to 2018
$3.7M
NEI NIH HHS R01 EY021281
6 · The paper itself

Abstract

purposeTo determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinal rim measurements.

methodsNinety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used. For each of the 48 minimum rim width (MRW) measurement points, we determined whether PRL were present, absent or indeterminate. When present, the proportion of PRL within the MRW was quantified.

resultsProtruded retinal layers were present in 503 (11.6%), absent in 3805 (88.1%) and indeterminate in 12 (0.3%) measurement points. Overall, 69 (76.6%) subjects had ≥1 points with PRL, with White subjects having the highest frequency and Japanese the lowest (29 [97%] and 18 [60%], respectively; p < 0.01). PRL were present in one-third of points in the temporal sector, but ≤5% in other sectors. When present, the median PRL thickness was 53.0 (interquartile range [IQR]: 33.0 to 78.5) μm, representing 20.6 (IQR: 13.0 to 28.5)% of MRW. Globally, the median PRL thickness comprised 1.3 (IQR: 0.2 to 3.5)% of the MRW; however, in the temporal sector, it exceeded 30% of MRW in some subjects.

conclusionsProtruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed. There were racial variations in the presence of PRL and a significantly higher frequency of PRL in the temporal sector.

Indexed as

AdultBruch MembraneFemaleGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedNerve FibersOptic DiskRetinal Ganglion CellsTomography, Optical Coherenceneuroretinal rimoptical coherence tomographyoptic nerve headretinal layers

Identifiers

PMID30105788
PMCPMC6093290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.