ArticleDrug delivery and translational research2018
In situ gel-forming system for dual BMP-2 and 17β-estradiol controlled release for bone regeneration in osteoporotic rats.
Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration.Bioactive materials · 2026Review
- Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review.Polymers · 2022Review
- Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane.International journal of nanomedicine · 2022Article
- The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status.Pharmaceutics · 2021Article
- Supramolecular Hydrogels for Protein Delivery in Tissue Engineering.Molecules (Basel, Switzerland) · 2021Review
- Release mechanisms of bovine serum albumin loaded-PLGA microspheres prepared by ultra-fine particle processing system.Drug delivery and translational research · 2020Article
- Organotypic culture as a research and preclinical model to study uterine leiomyomas.Scientific reports · 2020Article
- PLGA-BMP-2 and PLA-17β-Estradiol Microspheres Reinforcing a Composite Hydrogel for Bone Regeneration in Osteoporosis.Pharmaceutics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to evaluate the bone regeneration capacity of a Pluronic® F127 (P)-Tetronic®1307 (T) and α-cyclodextrin (CD) supramolecular gel (P-T-CD) in a 11/7/7 ratio containing BMP-2 and 17β-estradiol pre-encapsulated in poly-lactide-co-glycolide (PLGA) and poly-lactic acid (PLA-S) microspheres, respectively. Ovariectomy combined with dexamethasone treatment was used to induce an osteoporotic (OP) animal model of calvaria critical size defect in female rats to test the system. The two active substances showed a biphasic in vitro release profile characterized by an initial fast phase followed by a slow and prolonged release. The bone morphogenetic protein-2 (BMP-2) in vivo release was faster than in vitro. The in vivo experimental design included four groups of sham rats and other four groups of OP rats treated with the blank system, BMP-2, and one or two doses of BMP-2 combined with 17β-estradiol. After 12 weeks, histological and histomorphometric analyses showed that the combined treatment with BMP-2 and 17β-estradiol did not improve the repair response in sham, whereas in OP animals, a significant increase in the repair rate was observed with respect to the group treated with BMP-2 alone. However, the low values of osteocalcin, showed an immature and poorly mineralized new bone in OP animals. The second dose of the system with BMP-2 and 17β-estradiol did not improve the repair response in any case.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.