Evidence map›Paper›PMID 30105666›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Risk factors and prediction model for persistent breast-cancer-related lymphedema: a 5-year cohort study.

I-Wen Penn, Yue-Cune Chang, Eric Chuang, Chi-Ming Chen, Chi-Feng Chung, Chia-Yu Kuo, Tien-Yow Chuang

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Upper limb sensory evaluations and ultrasonographic skin measurements in breast cancer-related lymphedema receiving complex decongestive physiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

I-Wen PennDepartment of Rehabilitation Medicine, Koo-Foundation Sun Yat-Sen Cancer Center, No.125 Lih-Der Road, Pei-Tou District, Taipei City, 112, Taiwan.
Yue-Cune ChangDepartment of Mathematics, Tamkang University, No.151, Yingzhuan Rd., Tamsui District, New Taipei City, 25137, Taiwan.
Eric ChuangDepartment of Integrative Biology Alumnus, University of California, 3040 Valley Life Sciences Building #3140, Berkeley, CA, 94720-3140, USA.
Chi-Ming ChenDepartment of Surgery, Koo-Foundation Sun Yat-Sen Cancer Center, No.125 Lih-Der Road, Pei-Tou District, Taipei City, 112, Taiwan.
Chi-Feng ChungDepartment of Hematology and Medical Oncology, Koo-Foundation Sun Yat-Sen Cancer Center, No.125 Lih-Der Road, Pei-Tou District, Taipei City, 112, Taiwan.
Chia-Yu KuoDepartment of Physical Medicine and Rehabilitation, National Yang-Ming University and Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan.
Tien-Yow ChuangSchool of Medicine, Fu Jen Catholic University, No.510 Zhongzheng Road, Xinzhuang District, Taipei City, 242, Taiwan. tychuang@vghtpe.gov.tw.ORCID http://orcid.org/0000-0001-7320-1469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreast-cancer-related lymphedema (BCRL) can be a transient or persistent condition. The aims of this study were to (1) identify and weigh the risk factors for persistent lymphedema (PLE) among all patients with BCRL and (2) establish a prediction model for the occurrence of PLE.

methodsA cohort of 342 patients with BCRL with a median follow-up of 5 years after the onset of swelling was analyzed. PLE was defined as a hardening of the subcutaneous tissue, the persistence of the circumferential difference (CD) between arms, or a flare-up of swelling during follow-up. Multiple logistic regression was used to identify risk factors for PLE, including tumors, treatments, and patient-related factors. The prediction accuracy of the model was assessed using the area under the receiver operating characteristic curve (AUC).

resultsOf the 342 patients with BCRL, 229 (67%) had PLE. Multiple logistic regression analysis revealed that the number of lymph node metastases (p = 0.012), the maximal CD between arms at the first occurrence of swelling (p < 0.001), and the largest difference during follow-up (p < 0.001) were significant predictors for PLE. The corresponding AUC was 0.908. Although inclusion of body weight gains (p = 0.008) and maximal CD at the latest follow-up (p = 0.002) increased the analytical accuracy (AUC = 0.920), the resulting AUC values (p = 0.113) were not significantly different.

conclusionsBCRL is persistent in two thirds of patients. Patients with more lymph node metastases, weight gain, and larger CD since the onset of swelling and during follow-up have an increased likelihood of developing PLE.

Indexed as

AdultBreast Cancer LymphedemaBreast NeoplasmsFemaleHumansLogistic ModelsLongitudinal StudiesLymphatic MetastasisLymphedemaLymph Node ExcisionMiddle AgedRetrospective StudiesRisk FactorsROC CurveTaiwanBreast cancerLymphedemaPersistent lymphedemaPrediction modelRisk factors

Identifiers

PMID30105666
PMCPMC6373263

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.