ArticleGeneral thoracic and cardiovascular surgery2018
Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ratio in pathological stage IIIA (N2-positive) non-small cell lung cancer patients.
Article in General thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Development and application of a risk prediction nomogram for sarcopenia one year after surgery in early-stage non-small cell lung cancer patients.Frontiers in medicine · 2026Article
- Global trends in sarcopenia and cancer over the past 10 years: a bibliometric analysis.Discover oncology · 2025Article
- Psoas muscle index as a novel measure of frailty and predictor of post-operative outcome in octogenarians with non-small cell lung cancer.Journal of thoracic disease · 2025Article
- Impact of low preoperative appendicular skeletal muscle mass on postoperative complications and short-term outcomes in liver transplant recipients: a propensity score-matched retrospective study.Frontiers in surgery · 2025Article
- Article
- An independent prognostic factor in surgical cases of pleural empyema caused by common bacteria is the presence of a fistula.General thoracic and cardiovascular surgery · 2023Article
- Multidisciplinary treatment of thoracic fistulous empyema caused by pulmonary infection: a retrospective study.Multidisciplinary respiratory medicine · 2023Article
- Article
- Impact of sarcopenia on the prognosis and treatment of lung cancer: an umbrella review.Discover oncology · 2022Review
- Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis.Lung · 2022Review
- Association between platelet, white blood cell count, platelet to white blood cell ratio and sarcopenia in community-dwelling older adults: focus on Bushehr Elderly Health (BEH) program.BMC geriatrics · 2022Article
- Prognostic Values of Inflammatory Indexes and Clinical Factors in Patients with Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma and Treated with Tyrosine Kinase Inhibitors.Journal of personalized medicine · 2022Article
- Does sarcopenia affect postoperative short- and long-term outcomes in patients with lung cancer?-a systematic review and meta-analysis.Journal of thoracic disease · 2021Article
- Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer.PloS one · 2021Article
- Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass.Acta physiologica (Oxford, England) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSurgical indication in stage IIIA (N2) non-small cell lung cancer is still controversial. Hence, there is a need for the identification of predictors of the postoperative outcome in these patients. Although sarcopenia is expected to be a novel predictor of postoperative outcome in these patients, the underlying clinical features of sarcopenia have not been well investigated. Elevation of neutrophil/lymphocyte ratio indicates cancer-associated inflammation and depression of anticancer immunity. We analyzed the influence of sarcopenia on postoperative prognosis, and investigated the relationship between sarcopenia and neutrophil/lymphocyte ratio in patients with stage IIIA (N2) non-small cell lung cancer.
methodsWe retrospectively investigated 69 patients with stage IIIA (N2) non-small cell lung cancer. We used the L3 muscle index as a clinical measurement of sarcopenia, and divided patients into the sarcopenic (n = 21) and the non-sarcopenic group (n = 48). We then investigated the effect of sarcopenia on postoperative prognosis, and evaluated the correlation between sarcopenia and neutrophil/lymphocyte ratio.
resultsThis study included 47 males and 22 females. Univariate analysis revealed that sarcopenia, performance status, and serum cytokeratin-19 fragment level were predictors of poor prognosis; multivariate analysis revealed that performance status and sarcopenia were independent predictors of poor prognosis. The presence of sarcopenia was significantly correlated with neutrophil/lymphocyte ratio elevation.
conclusionsSarcopenia is a novel predictor of poor prognosis in patients with stage IIIA (N2) non-small cell lung cancer. Neutrophil/lymphocyte ratio elevation might be the reason for poor prognosis in sarcopenic patients.
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