Evidence map›Paper›PMID 30105585›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2019

Regulation of human brown adipose tissue by adenosine and A

Minna Lahesmaa, Vesa Oikonen, Semi Helin, Pauliina Luoto, Mueez U Din, Alexander Pfeifer, Pirjo Nuutila, Kirsi A Virtanen

Erratum issuedOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Energy Regulation in Inflammatory Sarcopenia by the Purinergic System.International journal of molecular sciences · 2023
    Review
  5. Modern and Non-Invasive Methods of Fat Removal.Medicina (Kaunas, Lithuania) · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Structure and function of adenosine receptor heteromers.Cellular and molecular life sciences : CMLS · 2021
    Review
  14. Allosteric Interactions between Adenosine AInternational journal of molecular sciences · 2021
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Frontiers in pharmacology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Minna LahesmaaTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Vesa OikonenTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Semi HelinTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Pauliina LuotoTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Mueez U DinTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.
Pirjo NuutilaTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland.
Kirsi A VirtanenTurku PET Centre, University of Turku, P.O. Box 52, FI-20520, Turku, Finland. kirsi.virtanen@utu.fi.
University of Turku · FITurku PET Centre · FIUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBrown adipose tissue (BAT) has emerged as a potential target to combat obesity and diabetes, but novel strategies to activate BAT are needed. Adenosine and A

methodsHealthy, lean men (n = 10) participated in PET/CT imaging with two radioligands. Perfusion of BAT, white adipose tissue (WAT) and muscle was quantified with [

resultsAdenosine increased the perfusion of BAT even more than cold exposure (baseline 8.3 ± 4.5, cold 19.6 ± 9.3, adenosine 28.6 ± 7.9 ml/100 g/min, p < 0.01). Distribution volume of [

conclusionsAdenosine administration caused a maximal perfusion effect in human supraclavicular BAT, indicating increased oxidative metabolism. Cold exposure increased noradrenaline concentrations and decreased the density of A2AR available for radioligand binding in BAT, suggesting augmented release of endogenous adenosine. Our results show that adenosine and A2AR are relevant for activation of human BAT, and A2AR provides a future target for enhancing BAT metabolism.

Indexed as

Oxygen RadioisotopesPositron Emission Tomography Computed TomographyWaterXanthinesAdenosineAdipose Tissue, BrownAdolescentAdultCold TemperatureEnergy MetabolismFatty Acids, NonesterifiedFemaleHumansMaleNorepinephrineReceptor, Adenosine A2AAdenosineFatty Acids, NonesterifiedKF18446NorepinephrineOxygen-15Oxygen RadioisotopesReceptor, Adenosine A2AWaterXanthines[11C]TMSX[15O]H2OA2A receptorAdenosineBrown adipose tissuePerfusionPhysiologyPositron emission tomography

Identifiers

PMID30105585
PMCPMC6351510
OpenAlexW2886313689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.