ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2018
[Acute diseases of the brain and heart : A reciprocal culprit-victim relationship].
Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke.Frontiers in neurology · 2025Article
- Clinical applications of artificial intelligence and machine learning in neurocardiology: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke.BMC neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reciprocal culprit-victim relationship between the brain and the heart leads to dysfunction and damage to the other organ, especially in acute and severe diseases of one of both organs. In addition, both organ systems can be affected by identical systemic processes, e. g., arteriosclerotic changes. Cardiac embolic formation and pumping failure lead to focal cerebral ischemia or global hypoxia. Cerebral diseases leading to cardiac changes are acute cerebrovascular attacks such as cerebral infarction, intracerebral hemorrhage and subarachnoid hemorrhage, as well as epileptic seizures. The pathophysiological mechanisms of changes of the brain-heart axis include cerebrally induced autonomic dysregulation, neuroendocrine regulatory disorders, and systemic inflammatory processes. The effects on the heart are evident in up to 75% of patients with acute brain diseases leading to ECG changes, arrhythmias, increase in cardiac enzymes and myocardial damage even to sudden cardiac death. For this reason, cardiac monitoring should be provided in severe acute brain diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.