Evidence map›Paper›PMID 30105556›Full record

ArticleMolecular diversity2019

Regioselective formation of 1,2,4-triazoles by the reaction of amidrazones in the presence of diethyl azodicarboxylate and catalyzed by triethylamine.

Ashraf A Aly, Alaa A Hassan, Nasr K Mohamed, Mohamed Ramadan, Alan B Brown, Amal S Abd El-Aal, Stefan Bräse, Martin Nieger

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Ashraf A AlyChemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt. ashrafaly63@yahoo.com.
Alaa A HassanChemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt.
Nasr K MohamedChemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt.
Mohamed RamadanOrganic Pharmacy Department, Faculty of Pharmacy, Al-Azhar Branch of Assiut University, Assiut, Egypt.
Alan B BrownChemistry Department, Florida Institute of Technology, Melbourne, FL, 32901, USA.
Amal S Abd El-AalChemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt.
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.
Martin NiegerDepartment of Chemistry, University of Helsinki, PO Box 55, A. I. Virtasen aukio 1, 00014, Helsinki, Finland.
Minia University · EGAssiut University · EGFlorida Institute of Technology · USKarlsruhe Institute of Technology · DEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of amidrazones with ethyl azodicarboxylate and triethylamine (Mitsunobu reagent) in EtOH. This highly regioselective one-pot process provides rapid access to highly diverse triazoles. The reaction was explained, based on Mitsunobu reagent oxidizing ethanol to acetaldehyde, which would then react with amidrazones to give the substituted 3-methyltriazoles. A [2 + 3] cycloaddition reaction between two oxidized forms of amidrazones produced the second type of triazoles. X-ray structure analyses proved the structure of each type of product.

Indexed as

Azo CompoundsCatalysisDicarboxylic AcidsEthylaminesTriazoles1,2,4-triazoleAzo CompoundsDicarboxylic AcidsEthylaminesTriazolestriethylamine1,2,4-TriazolesAmidrazonesMitsunobu reagentRegioselective

Identifiers

PMID30105556
OpenAlexW2886920013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.