Evidence map›Paper›PMID 30105555›Full record

ReviewCurrent cardiology reports2018

Genetics of Dilated Cardiomyopathy: Clinical Implications.

A Paldino, G De Angelis, M Merlo, M Gigli, M Dal Ferro, G M Severini, L Mestroni, G Sinagra

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. [Clinical and genetic characteristics of children with primary dilated cardiomyopathy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  10. Review
  11. Article
  12. Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies.Journal of the American College of Cardiology · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Myocarditis: Which Role for Genetics?Current cardiology reports · 2021
    Review
  17. Review
  18. Article
  19. [Why do we need genetics in cardiac rhythmology?]Herzschrittmachertherapie & Elektrophysiologie · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

A PaldinoCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy.
G De AngelisCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy.
M MerloCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy. marco.merlo79@gmail.com.
M GigliCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy.
M Dal FerroCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy.
G M SeveriniMedical Genetics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
L MestroniCardiovascular Institute and Adult Medical Genetics Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
G SinagraCardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste (ASUITs), Via P. Valdoni, 7, 34100, Trieste, Italy.
Azienda Sanitaria Universitaria Integrata di Trieste · ITUniversity of Trieste · ITIRCCS Materno Infantile Burlo Garofolo · ITUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review aims to summarize the current knowledge on the genetic background of dilated cardiomyopathy (DCM), with particular attention to the genotype-phenotype correlations and the possible implications for clinical management. RECENT

findingsNext generation sequencing (NGS) has led to the identification of an increasing number of genes and mutations responsible for DCM. This genetic variability is probably related to the extreme heterogeneity of disease manifestation. Important findings have associated mutations of Lamin A/C (LMNA) and Filamin C (FLNC) to poor prognosis and the propensity to cause an arrhythmic phenotype, respectively. However, a deeper understanding of the genotype-phenotype correlation is necessary, because it could have several implications for the clinical management of the patients. Furthermore, the correct interpretation of pathogenicity of mutations and the clinical impact of genetic testing in DCM patients still represent important fields to be implemented. A pathogenic gene mutation can be identified in almost 40% of DCM patients. The recent discoveries and future research in the field of genotype-phenotype correlation may lead to a more personalized management of the mutation carriers towards the application of precision medicine in DCM.

Indexed as

MutationArrhythmias, CardiacCardiomyopathy, DilatedDeath, Sudden, CardiacGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansPrognosisRisk AssessmentRisk FactorsGenetic MarkersDilated cardiomyopathyFilamin CGenotype-phenotype correlationLamin A/CNext generation sequencingPrecision medicine

Identifiers

PMID30105555
OpenAlexW2887562761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.