SynthesisPediatric surgery international2018
Gastroesophageal reflux in children with neurological impairment: a systematic review and meta-analysis.
Synthesis in Pediatric surgery international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Dietary management and feeding considerations of pediatric aerodigestive and upper gastrointestinal motility disorders.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Gastrostomy plus fundoplication or gastro-jejunal tube or gastrostomy alone for treating or preventing gastro-esophageal reflux in children and adolescents with neurological impairment.The Cochrane database of systematic reviews · 2026Pooled it
- Pooled it
- Do pediatric patients with cerebral palsy have worse outcomes after anti-reflux esophageal surgery?Pediatric surgery international · 2026Article
- Case Report: Robot-assisted nissen fundoplication in spinal muscular atrophy type 2-a tailored surgical and anaesthetic strategy.Frontiers in surgery · 2026Article
- Article
- Laparoscopic "TOUSSEN" fundoplication for pediatric gastroesophageal reflux disease: a new modified technique gentle as Toupet and solid as Nissen?Pediatric surgery international · 2025Article
- Surgical Management of Gastroesophageal Reflux in Neurologically Impaired Children: Fundoplication vs. Total Esophagogastric Dissociation.Journal of clinical medicine · 2025Article
- Fundoplication for Pediatric Gastroesophageal Reflux Disease: Indications, Techniques, and Outcomes.Cureus · 2024Article
- Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomized Controlled Trials.Children (Basel, Switzerland) · 2024Review
- Article
- Gastroesophageal reflux disease in children: What's new right now?World journal of gastrointestinal endoscopy · 2023Review
- Perioperative outcomes of laparoscopic fundoplication for gastroesophageal reflux disease in children with or without scoliosis.Pediatric surgery international · 2021Article
- Differential gastric emptiness according to preoperative stomach position in neurological impaired patients who underwent laparoscopic fundoplication and gastrostomy.Surgery today · 2021Article
- Isolated neutropenia caused by copper deficiency due to jejunal feeding and excessive zinc intake: A case report.World journal of clinical cases · 2021Article
- Is There a Role for Elective Early Upper Gastrointestinal Contrast Study in Neurologically Impaired Children following Laparoscopic Nissen Fundoplication?Children (Basel, Switzerland) · 2021Article
- Long-Term Analysis of Respiratory-Related Complications Following Gastrostomy Placement with or without Fundoplication in Neurologically Impaired Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2021Article
- A narrative review of gastroesophageal reflux in the pediatric patient.Translational gastroenterology and hepatology · 2021Review
- Multi-Organ Dysfunction in Cerebral Palsy.Frontiers in pediatrics · 2021Review
- Gastroesophageal reflux in children: an updated review.Drugs in context · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurologically impaired children (NIC) suffer severe gastroesophageal reflux (GER) with poor fundoplication outcome. Aims of the study were: (1) to determine the recurrence of GER after fundoplication in NIC; (2) to compare fundoplication versus gastro-jejunal tube feeding insertion (GJ) and fundoplication versus total esophagogastric dissociation (TEGD) in primarily treating GER in NIC. Using defined search strategy, two investigators identified all comparative studies reporting the mentioned procedures to primarily treat GER in NIC. The study was conducted under PRISMA guidelines. The meta-analysis was performed using RevMan 5.3. Data are mean ± SD. Of 3840 titles/abstracts screened, 14 studies on fundoplication (2716 pts.) reported a recurrence/persistence of GER higher in NIC (14.2 ± 8.3%) than in neurologically normal (9.4 ± 5.2%; p = 0.0001), with an increased incidence of re-do fundoplication (12.6 ± 7.0% versus 9.1 ± 4.5%; p < 0.01). Three studies revealed a similar risk of undergoing subsequent fundoplication after GJ (4.9 ± 2.1%) or initial fundoplication (12.0 ± 0.6%; p = ns). Four studies showed a lower recurrence of GER following TEGD (1.4 ± 1.1%) than fundoplication (24.8 ± 1.4%; p = 0.002). NIC are at risk of recurrence/persistence of GER after fundoplication or GJ. TEGD seems more effective to primarily treat GER in NIC. Prospective randomized controlled trials are necessary to establish which is the ideal treatment of GER in NIC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.