Evidence map›Paper›PMID 30105314›Full record

ArticleAPL bioengineering2018

Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span.

Ayla O Sessions, Peter Min, Thekla Cordes, Barry J Weickert, Ajit S Divakaruni, Anne N Murphy, Christian M Metallo, Adam J Engler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Bioengineering of the heart.APL bioengineering · 2020
    Article
  3. A Review ofFrontiers in bioengineering and biotechnology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ayla O SessionsBiomedical Sciences Program, UC San Diego, La Jolla, California 92093, USA.
Peter MinDepartment of Bioengineering, UC San Diego, La Jolla, California 92093, USA.
Thekla CordesDepartment of Bioengineering, UC San Diego, La Jolla, California 92093, USA.
Barry J WeickertDepartment of Bioengineering, UC San Diego, La Jolla, California 92093, USA.
Ajit S DivakaruniDepartment of Pharmacology, UC San Diego, La Jolla, California 92093, USA.
Anne N MurphyDepartment of Pharmacology, UC San Diego, La Jolla, California 92093, USA.
Christian M MetalloDepartment of Bioengineering, UC San Diego, La Jolla, California 92093, USA.
Adam J EnglerBiomedical Sciences Program, UC San Diego, La Jolla, California 92093, USA.
University of California San Diego · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK, THOMAS KAUFMAN · 2014 to 2026
$13.5M
Mechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionR01AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2013 to 2022
$3.4M
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative diseaseR01NS087611 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A, MURPHY, ANNE N. · 2014 to 2018
$2.9M
Exploiting Metabloic Defects in Tumors with Mutant IDH1 and IDH2R01CA188652 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI METALLO, CHRISTIAN MICHAEL · 2014 to 2018
$1.6M
Cell-Matrix Contacts Regulate Age-Associated Cardiac FunctionF31HL131137 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SESSIONS, AYLA O · 2016 to 2016
$26k
NCI NIH HHS R01 CA188652NHLBI NIH HHS F31 HL131137NIA NIH HHS R01 AG045428NIH HHS P40 OD018537NINDS NIH HHS R01 NS087611
6 · The paper itself

Abstract

Despite limited regenerative capacity as we age, cardiomyocytes maintain their function in part through compensatory mechanisms, e.g., Vinculin reinforcement of intercalated discs in aged organisms. This mechanism, which is conserved from flies to non-human primates, creates a more crystalline sarcomere lattice that extends lifespan, but systemic connections between the cardiac sarcomere structure and lifespan extension are not apparent. Using the rapidly aging fly system, we found that cardiac-specific Vinculin-overexpression [Vinculin heart-enhanced (

Identifiers

PMID30105314
PMCPMC6086353
OpenAlexW2883697376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.