Evidence map›Paper›PMID 30105166›Full record

ReviewNeurology. Clinical practice2018

Exercise for cognitive brain health in aging: A systematic review for an evaluation of dose.

Joyce Gomes-Osman, Danylo F Cabral, Timothy P Morris, Katalina McInerney, Lawrence P Cahalin, Tatjana Rundek, Augusto Oliveira, Alvaro Pascual-Leone

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology. Clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04841668 (Gut-Brain-axis), which is not on this map. Cited by 101 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04841668 completedstarted 2021, after this paper: background citation

Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Ran2021Enrolled50Registered outcomes51Posted comparisons0ConditionsType 2 Diabetes MellitusArmsMetformin
PMID 8013758PMID 30397356PMID 16443885PMID 11118008PMID 18220635PMID 12086935PMID 28500216PMID 12930161PMID 16219009PMID 11602624PMID 23900241PMID 8532986other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joyce Gomes-OsmanBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Danylo F CabralBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Timothy P MorrisBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Katalina McInerneyBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Lawrence P CahalinBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Tatjana RundekBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Augusto OliveiraBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
Alvaro Pascual-LeoneBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology (JG-O, TPM, AP-L), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Departments of Physical Therapy (JG-O, DFC, LPC), Neurology (JG-O, KM, TR), and Evelyn F. McKnight Institute (JG-O, TR), University of Miami Miller School of Medicine, FL; Departamento de Fisioterapia (DFC, AO), Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil; Departament de Psicobiologia i Ciències de la Salut (AP-L), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain; and Institut Guttmann (TPM, AP-L), Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.

Funding

Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
NCATS NIH HHS KL2 TR002737
6 · The paper itself

Abstract

purpose of reviewWe systematically appraised randomized controlled trials proposing exercise to influence cognition in older adults to (1) assess the methodologic quality using Cochrane criteria; (2) describe various exercise dose measures and assess their relationship with improved cognitive performance; and (3) identify consistent patterns of reported effects on cognition. RECENT

findingsThere was overall good methodologic quality in all 98 included studies. The assessment of the relationship between improved cognition and various measures of exercise dose (session duration, weekly minutes, frequency, total weeks, and total hours) revealed a significant correlation with total hours. Improvements in global cognition, processing speed/attention, and executive function were most stable and consistent. SUMMARY: We found that exercising for at least 52 hours is associated with improved cognitive performance in older adults with and without cognitive impairment. Exercise modes supported by evidence are aerobic, resistance (strength) training, mind-body exercises, or combinations of these interventions.

Identifiers

PMID30105166
PMCPMC6075983

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.