Evidence map›Paper›PMID 30105161›Full record

ArticleNeurology. Clinical practice2018

What predicts falls in Parkinson disease?: Observations from the Parkinson's Foundation registry.

Sotirios A Parashos, Bastiaan R Bloem, Nina M Browner, Nir Giladi, Tanya Gurevich, Jeffrey M Hausdorff, Ying He, Kelly E Lyons, Zoltan Mari, John C Morgan and 3 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Neurology. Clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 3 countries.

Sotirios A ParashosStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Bastiaan R BloemStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Nina M BrownerStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Nir GiladiStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Tanya GurevichStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Jeffrey M HausdorffStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Ying HeStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Kelly E LyonsStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Zoltan MariStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
John C MorganStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Bart PostStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Peter N SchmidtStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Catherine L WielinskiStruthers Parkinson's Center (SAP, CLW), HealthPartners, Golden Valley, MN; Parkinson Center Nijmegen (BRB, BP), Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Department of Neurology, the Netherlands; Department of Neurology (NMB), University of North Carolina at Chapel Hill; Neurological Institute (NG, TG, JMH), Tel Aviv Sourasky Medical Center, Sackler School of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Israel; Department of Mathematics (YH), Clarkson University, Potsdam, NY; University of Kansas Medical Center Parkinson's Disease Center (KEL), Kansas City; Department of Neurology (ZM), Johns Hopkins University, Baltimore, MD, currently at Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV; Movement Disorders Program (JCM), NPF Center of Excellence, Department of Neurology, Medical College of Georgia, Augusta University; Parkinson's Foundation (PNS), Miami, FL; and Department of Biostatistics (SSW), University of Florida, Gainesville.
Lou Ruvo Brain Institute · USTel Aviv University · ILUniversity of Kansas Medical Center · USParkinson's Foundation · USRadboud University Medical Center · NLRadboud University Nijmegen · NLUniversity of North Carolina at Chapel Hill · USHealthPartners · USJohns Hopkins University · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
6 · The paper itself

Abstract

backgroundWe undertook this study to identify patients with Parkinson disease (PD) with no or rare falls who may progress to frequent falling by their next annual follow-up visit.

methodsWe analyzed data in the National Parkinson Foundation Quality Improvement Initiative database to identify factors predicting which patients with PD with no or rare falls at the baseline visit will report at least monthly falls at the annual follow-up visit. Multivariable models were constructed using logistic regression. Variables were introduced in 4 blocks: in the 1st block, variables present at or before the baseline visit were entered; in the 2nd, baseline visit assessments; in the 3rd, interventions implemented during baseline visit; and, in the 4th block, changes in comorbidities, living situation, and treatment between visits.

resultsOf 3,795 eligible participants, 3,276 (86.3%) reported no or rare falls at baseline visit, and of them, 382 (11.7%) reported at least monthly falls at follow-up visit. Predictors included female sex, <90% diagnostic certainty, motor fluctuations, levodopa treatment, antidepressant treatment, prior deep brain stimulation (DBS), worse quality of life, Hoehn & Yahr stage 2 or 3, worse semantic fluency, and, between visits, addition of amantadine, referral to occupational therapy, social services, or DBS, new diagnoses of cancer or osteoarthritis, and increased emergency visits.

conclusionsThis large-scale analysis identified several predictors of progression to falling in PD. Such identifiers may help target patient subgroups for falls prevention intervention. Some factors are modifiable, offering opportunities for developing such interventions.

Identifiers

PMID30105161
PMCPMC6075989
OpenAlexW2803253478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.