Evidence map›Paper›PMID 30105034›Full record

ArticleFrontiers in immunology2018

The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status.

Maren Kasper, Karoline Walscheid, Björn Laffer, Dirk Bauer, Martin Busch, Lena Wildschütz, Bo Wang, Karin Loser, Thomas Vogl, Rafael S Grajewski and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Maren KasperDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Karoline WalscheidDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Björn LafferDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Dirk BauerDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Martin BuschDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Lena WildschützDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Bo WangDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
Karin LoserDepartment of Dermatology, University of Münster, Münster, Germany.
Thomas VoglInstitute of Immunology at University of Münster, Münster, Germany.
Rafael S GrajewskiDepartment of Ophthalmology, University of Cologne, Cologne, Germany.
Thomas LangmannChair of Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Arnd HeiligenhausDepartment of Ophthalmology and Ophtha-Laboratory at St. Franziskus Hospital, Münster, Germany.
St. Franziskus Hospital · DEUniversity of Cologne · DEUniversity of Münster · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HLA-B27 is the allele most frequently associated with human anterior uveitis. The majority of HLA-B27-positive [acute anterior uveitis (AAU)] patients develop clinically distinct symptoms with acute symptomatic onset of flare and a recurrent disease course characterized by a massive cellular ocular infiltrate during uveitis relapse. By contrast, uveitis in HLA-B27-negative [idiopathic anterior uveitis (IAU)] patients tends to develop a clinically less fulminant, more chronic, and typically asymptomatic disease course. To analyze systemic immune responses in the different uveitis entities, we analyzed peripheral blood cells by flow cytometry. In addition, as a pro-inflammatory biomarker serum, S100A8/A9 levels were quantified by ELISA from patients with AAU (

Indexed as

AdultAutoimmunityBiomarkersCalgranulin ACalgranulin BCase-Control StudiesCytokinesFemaleHLA-B27 AntigenHumansImmunophenotypingMaleMiddle AgedMonocytesMyeloid-Derived Suppressor CellsPhenotypeBiomarkersCalgranulin ACalgranulin BCytokinesHLA-B27 AntigenS100A8 protein, humanS100A9 protein, humanautoimmunitycytokineHLA-B27immunopathogenesismonocytesmyeloid-derived suppressor cellsuveitis

Identifiers

PMID30105034
PMCPMC6077321
OpenAlexW2887265928

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.