Evidence map›Paper›PMID 30105033›Full record

ReviewFrontiers in immunology2018

Uncovering the Mysteries of Langerhans Cells, Inflammatory Dendritic Epidermal Cells, and Monocyte-Derived Langerhans Cell-Like Cells in the Epidermis.

Masayuki Otsuka, Gyohei Egawa, Kenji Kabashima

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
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  12. Observational
  13. CD4Frontiers in immunology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Masayuki OtsukaDepartment of Dermatology, Graduate School of Medicine, Kyoto, Japan.
Gyohei EgawaDepartment of Dermatology, Graduate School of Medicine, Kyoto, Japan.
Kenji KabashimaDepartment of Dermatology, Graduate School of Medicine, Kyoto, Japan.
Kyoto University · JPSingapore Immunology Network · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identity of Langerhans cells (LCs) has been called into question of late due to the increasing evidence that LCs originate from macrophage lineage instead of dendritic cell (DC) lineage as previously thought. For many years, LCs have been assumed to be DCs due to its migratory capabilities. However, recent studies have demonstrated that LCs are from macrophage lineage of the adult fetal liver (FL) progenitor.

Indexed as

AnimalsAntigen-Presenting CellsCell DifferentiationCell MovementDendritic CellsDermatitisDisease SusceptibilityEpidermal CellsEpidermisHumansLangerhans CellsMacrophagesMonocytesPhenotypedendritic cellsinflammatory dendritic epidermal cellsLangerhans cellsresident macrophagesskin inflammation

Identifiers

PMID30105033
PMCPMC6077183
OpenAlexW2886548594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.