ArticleFrontiers in neural circuits2018
Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice.
Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Dopaminergic Inhibition of the Inwardly Rectifying Potassium Current in Direct Pathway Medium Spiny Neurons in Normal and Parkinsonian Striatum.Brain sciences · 2025Article
- Age-dependent impairment of dopamine D1 receptor signalling in mouse striatum byBrain communications · 2025Article
- An ultra low frequency spike timing dependent plasticity based approach for reducing alcohol drinking.Scientific reports · 2024Article
- Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia.bioRxiv : the preprint server for biology · 2024Article
- Clinico-physiological correlates of Parkinson's disease from multi-resolution basal ganglia recordings.NPJ Parkinson's disease · 2024Article
- Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input.Cell reports · 2024Article
- Bidirectional regulation of levodopa-induced dyskinesia by a specific neural ensemble in globus pallidus external segment.Cell reports. Medicine · 2024Article
- Rationale and Development of Tavapadon, a D1/D5-Selective Partial Dopamine Agonist for the Treatment of Parkinson's Disease.CNS & neurological disorders drug targets · 2024Review
- Dopamine-independent development and maintenance of mouse striatal medium spiny neuron dendritic spines.Neurobiology of disease · 2023Article
- Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging.PloS one · 2023Article
- Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding.Cell reports · 2022Article
- Circuit Mechanisms of L-DOPA-Induced Dyskinesia (LID).Frontiers in neuroscience · 2021Review
- Evolving concepts on bradykinesia.Brain : a journal of neurology · 2020Review
- Circuit Mechanisms of Neurodegenerative Diseases: A New Frontier With Miniature Fluorescence Microscopy.Frontiers in neuroscience · 2019Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Dopamine (DA) profoundly stimulates motor function as demonstrated by the hypokinetic motor symptoms in Parkinson's disease (PD) and by the hyperkinetic motor side effects during dopaminergic treatment of PD. Dopamine (DA) receptor-bypassing, optogenetics- and chemogenetics-induced spike firing of striatal DA D1 receptor (D1R)-expressing, direct pathway medium spiny neurons (dSPNs or dMSNs) promotes movements. However, the endogenous D1R-mediated effects, let alone those of DA replacement, on dSPN spike activity in freely-moving animals is not established. Here we show that using transcription factor Pitx3 null mutant (Pitx3Null) mice as a model for severe and consistent DA denervation in the dorsal striatum in Parkinson's disease, antidromically identified striatonigral neurons (D1R-expressing dSPNs) had a lower baseline spike firing rate than that in DA-intact normal mice, and these neurons increased their spike firing more strongly in Pitx3Null mice than in WT mice in response to injection of L-dopa or the D1R agonist, SKF81297; the increase in spike firing temporally coincided with the motor-stimulating effects of L-dopa and SKF81297. Taken together, these results provide the first evidence from freely moving animals that in parkinsonian striatum, identified behavior-promoting dSPNs become hyperactive upon the administration of L-dopa or a D1 agonist, likely contributing to the profound dopaminergic motor stimulation in parkinsonian animals and PD patients.
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