ReviewCancer management and research2018
Targeting energy metabolism to eliminate cancer cells.
Review in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- MiR-365-3p inhibits lung cancer proliferation and migration via CPT1A-mediated fatty acid oxidation.Scientific reports · 2025Article
- Research Hotspots and Trends in Global Cancer immunometabolism:A Bibliometric Analysis from 2000 to 2023.Journal of multidisciplinary healthcare · 2024Review
- The effect of ciprofloxacin on doxorubicin cytotoxic activity in the acquired resistance to doxorubicin in DU145 prostate carcinoma cells.Medical oncology (Northwood, London, England) · 2022Article
- 17-β Estradiol up-regulates energy metabolic pathways, cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids.Frontiers in oncology · 2022Article
- HOXC6 Regulates the Epithelial-Mesenchymal Transition through the TGF-Journal of oncology · 2022Article
- Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level.Cell death & disease · 2021Article
- The cytotoxic effect of Baeckea frustescens extracts in eliminating hypoxic breast cancer cells.BMC complementary medicine and therapies · 2021Article
- Article
- Expression of Autophagy and Mitophagy Markers in Breast Cancer Tissues.Frontiers in oncology · 2021Article
- Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer.Molecular and cellular biochemistry · 2020Article
- Combining transcatheter arterial embolization with iodized oil containing Apatinib inhibits HCC growth and metastasis.Scientific reports · 2020Article
- [Recombinant methioninase regulates PI3K/Akt/Glut-1 pathway and inhibits aerobic glycolysis to promote apoptosis of gastric cancer cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview.Frontiers in oncology · 2020Review
- The Multifaceted Effects of Autophagy on the Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients.Lab on a chip · 2019Article
- Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics.The EPMA journal · 2019Article
- Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma.Gastroenterology research · 2019Article
- Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma.Cancer management and research · 2019Article
- Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer.Cancer management and research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive metabolic responses toward a low oxygen environment are essential to maintain rapid proliferation and are relevant for tumorigenesis. Reprogramming of core metabolism in tumors confers a selective growth advantage such as the ability to evade apoptosis and/or enhance cell proliferation and promotes tumor growth and progression. One of the mechanisms that contributes to tumor growth is the impairment of cancer cell metabolism. In this review, we outline the small-molecule inhibitors identified over the past decade in targeting cancer cell metabolism and the usage of some of these molecules in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.