ArticleJournal of pain research2018
Comparison of percutaneous intradiscal ozone injection with laser disc decompression in discogenic low back pain.
Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06989632 (Total Lumbar Disc Prosthesis and Subsequent Work Activity 5 Years After Total Lumbar Disc Replacement), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total Lumbar Disc Prosthesis and Subsequent Work Activity 5 Years After Total Lumbar Disc Replacement
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- PERCUTANEOUS LASER DISC DECOMPRESSION FOR LUMBAR RADICULAR PAIN: A SYSTEMATIC REVIEW OF PUBMED IN THE LAST FIVE YEARS.Acta clinica Croatica · 2023Pooled it
- Clinical Effectiveness of Intradiscal Ozone Therapy with or Without Periforaminal Steroid Injection in Lumbar Disc Herniation: Revisiting an Underutilized Treatment.Journal of orthopaedic case reports · 2026Article
- Gas therapy: an innovative application for intervertebral disc degeneration.Medical gas research · 2026Review
- Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes.Animals : an open access journal from MDPI · 2026Article
- A Prospective Randomized Trial Comparing Effectiveness of Parasagittal and Midline Epidural Steroid Injection in Patients with Lumbar Canal Stenosis Pain.Anesthesiology and pain medicine · 2025Article
- How Effective is Ozone Therapy in Treatment of Lumbar Disc Disease: a Systematic Review of Prospective Studies.Maedica · 2024Article
- Erector Spinae Plane Block for the Treatment of Intractable Pain in a Patient with Pancoast Tumor: A Case Report.Anesthesiology and pain medicine · 2023Article
- The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study.Frontiers in neurology · 2023Article
- Intradiscal injection for the management of low back pain.JOR spine · 2022Article
- Role of Percutaneous Laser Disc Decompression in Patients with Lumbar Disc Herniation on Pain Relief: A Quasi-Experimental Pilot Study:.Galen medical journal · 2022Article
- Effects of calcitonin addition on epidural injection in patients with degenerative spinal canal stenosis: a randomized double blind clinical trial.Turkish journal of anaesthesiology and reanimation · 2021Article
- Percutaneous intradiscal injection of radiopaque gelified ethanol: short- and long-term functional outcome and complication rate in a consecutive series of patients with lumbar disc herniation.British journal of pain · 2021Article
- Adding Ozone to Dextrose and Somatropin for Intra-articular Knee Prolotherapy: A Randomized Single-Blinded Controlled Trial.Anesthesiology and pain medicine · 2020Article
- Short-Term Efficacy of Epidural Injection of Triamcinolone Through Translaminar Approach for the Treatment of Lumbar Canal Stenosis.Anesthesiology and pain medicine · 2020Article
- Reoccurring discogenic low back pain (LBP) after discoblock treated by oblique lumbar interbody fusion (OLIF).Journal of orthopaedic surgery and research · 2020Article
- The Successful Treatment of Herniated Lumbar Discs That are Refractory to Repeated Epidural Steroid Injection by Using a Navigable Percutaneous Disc Decompression Device: A Case Series.Journal of pain research · 2020Article
- Application of ozone therapy in interventional medicine.Journal of interventional medicine · 2019Article
- Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-Pain research & management · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntervertebral disc herniation with the pressure on the surrounding neural structures is one of the most important causes of chronic low back pain, which sometimes leads to open surgery. Reducing the pressure inside the disc with intradiscal intervention such as laser irradiation or ozone injection is a minimally invasive method and an alternative to surgery with satisfactory results. These two methods were compared with each other in this research. PATIENTS AND
methodsIn this clinical trial, 40 patients with back pain radiating to lower limb due to lumbar intervertebral disc herniation were selected. These patients were randomly divided into two equal groups for percutaneous intradiscal intervention. The Laser Disc Decompression Group (LDG) (n=20) was exposed to 1500 J of laser irradiation into the disc center. In the Ozone Injection Group (OZG) patients (n=20), 6 mL of ozone 30 µg/mL was injected into the center of the disc. Considering the level of neural root involvement, both groups received 20 mg of triamcinolone injection via transforaminal epidural. Patients were followed up for 12 months regarding score on visual analogue scale and life performance improvement based on Oswestry Disability Index (ODI) and satisfaction level.
resultsAccording to the results, no difference was found between the two groups for ODI variable before intervention, whereas OZG showed better ODI scores in the measured time intervals. In LDG, only a significant difference in terms of ODI score was found between the times of before surgery and the first month.
conclusionIntradiscal ozone injection could be an effective and cost-effective method for treatment of patients with discogenic back pain.
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