ArticleInternational journal of nanomedicine2018
Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Beta cyclodextrin stabilized cupric oxide nanoparticles assisted thermal therapy for lung tumor and its effective in vitro anticancer activity.Scientific reports · 2025Article
- Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway.Frontiers in pharmacology · 2025Article
- LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response.International journal of molecular medicine · 2023Article
- Conquering Cancer Multi-Drug Resistance Using Curcumin and Cisplatin Prodrug-Encapsulated Mesoporous Silica Nanoparticles for Synergistic Chemo- and Photodynamic Therapies.Nanomaterials (Basel, Switzerland) · 2022Article
- The TRPV1 Receptor Is Up-Regulated by Sphingosine 1-Phosphate and Is Implicated in the Anandamide-Dependent Regulation of Mitochondrial Activity in C2C12 Myoblasts.International journal of molecular sciences · 2022Article
- Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.Journal of molecular histology · 2022Article
- Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction.Frontiers in molecular neuroscience · 2022Article
- Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Article
- Visualization and characterization of metallo-aggregates using multi-photon microscopy.RSC advances · 2020Article
- Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation forRSC advances · 2020Article
- Formulation and characterization of folate receptor-targeted PEGylated liposome encapsulating bioactive compounds from3 Biotech · 2020Article
- The Development of Functional Non-Viral Vectors for Gene Delivery.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimIridium (Ir)-based complex is a potential antitumor ingredient, but its poor physicochemical properties such as hydrophobicity and low biocompatibility hamper further application. Liposome provides a potential delivery approach for improving the poor physicochemical property and reducing the side effects of antitumor drug. In this study, we aimed at incorporating Ir ([Ir(ppy) MATERIALS AND
methodsIr-loaded PEGylated liposomes (Lipo-Ir) were formulated by thin-film dispersion and ultrasonic method. Morphology, size distribution, and zeta potential of Lipo-Ir were examined by transmission electron microscopy (TEM) and Zetasizer. The released profile and biocompatibility were investigated by dialysis method and hemolysis test, respectively. Additionally, the cytotoxic activity and mechanism of Lipo-Ir and Ir inducing apoptosis in A549 cells were evaluated.
resultsLipo-Ir can keep sustained release, excellent biocompatibility, and physical stability. The average particle size, polydispersity index, zeta potential, encapsulation efficiency, and drug loading are 112.57±1.15 nm, 0.19±0.02, -10.66±0.61 mV, 94.71%±3.21%, and 4.71%±0.41%, respectively. 3-(4,5-dimethylthiazole)-2,5-diphenltetraazolium bromide (MTT) assay show that Lipo-Ir and Ir display high cytotoxicity against selected cancer cells. Furthermore, the apoptotic features of morphology, depolarization of mitochondrial membrane potential, increase in the reactive oxygen species (ROS) levels, and disorder of Ca
conclusionThe studies demonstrate that Lipo-Ir can trigger apoptosis in A549 cells via ROS-mediated mitochondrial dysfunctions, and the biocompatible and sustained Lipo-Ir will be a promising drug delivery system.
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