ArticleInternational journal of chronic obstructive pulmonary disease2018
Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Bacteria of the lung microbiome and health biomarkers in chronic airway disease: a systematic review and meta-analysis.NPJ biofilms and microbiomes · 2026Pooled it
- Dissecting the effect of single- and co-infection of TB and COVID-19 pathogens on the sputum microbiome.Microbiology spectrum · 2026Article
- Single-bacterial cell insights into mechanisms of ceftriaxone resistance in Neisseria subflava.Nature communications · 2026Article
- Gut-X axis.iMeta · 2025Review
- The Metabolic Potential of the Human Lung Microbiome.Microorganisms · 2024Article
- Sputum metagenomics of people with bronchiectasis.ERJ open research · 2024Article
- Exploring the potential role of microbiota and metabolites in acute exacerbation of chronic obstructive pulmonary disease.Frontiers in microbiology · 2024Article
- Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.Frontiers in immunology · 2022Review
- Extended Bacteria Culture-Based Clustering Identifies a Phenotype Associating Increased Cough andFrontiers in microbiology · 2021Article
- The sputum microbiome associated with different sub-types of AECOPD in a Chinese cohort.BMC infectious diseases · 2020Article
- Untangling Species-Level Composition of Complex Bacterial Communities through a Novel Metagenomic Approach.mSystems · 2020Article
- The sputum microbiome is distinct between COPD and health, independent of smoking history.Respiratory research · 2020Article
- Chronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study.Respiratory research · 2019Observational
- Chronic obstructive pulmonary disease upper airway microbiome is associated with select clinical characteristics.PloS one · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of airway microbiota in COPD is highly debated. Symptomology assessment is vital for the management of clinically stable COPD patients; however, the link between symp toms and the airway microbiome is currently unknown. Purpose: The present study aimed to evaluate the relationship among stable COPD patients. Patients and methods: We conducted pyrosequencing of bacterial 16S rRNA using induced sputum samples in a Han Chinese cohort that included 40 clinically stable COPD patients and 19 healthy controls. Results: Alterations in community composition and core bacte rial taxa (Neisseria subflava, etc.) were observed in patients with severe symptoms compared with controls. The co-occurrence network indicated that the key microbiota enriched in COPD patients showed higher expression in patients with severe symptoms. The association pattern of symptoms with the sputum microbiome was obviously different from that of lung function in COPD patients. Conclusion: These findings broaden our insights into the relationship between the sputum microbiota and the symptom severity in COPD patients, emphasizing the role of symptoms in the airway microbiome, independent of lung function.
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