Evidence map›Paper›PMID 30104797›Full record

ArticleBulletin of the World Health Organization2018

Cost-effectiveness of risk-based breast cancer screening programme, China.

Li Sun, Rosa Legood, Zia Sadique, Isabel Dos-Santos-Silva, Li Yang

Abstract read
In one paragraph

Article in Bulletin of the World Health Organization, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li SunDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, England.
Rosa LegoodDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, England.
Zia SadiqueDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, England.
Isabel Dos-Santos-SilvaDepartment of Noncommunicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, England.
Li YangSchool of Public Health, Peking University, NO.38 Xueyuan Road, Haidian District, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo model the cost-effectiveness of a risk-based breast cancer screening programme in urban China, launched in 2012, compared with no screening.

methodsWe developed a Markov model to estimate the lifetime costs and effects, in terms of quality-adjusted life years (QALYs), of a breast cancer screening programme for high-risk women aged 40-69 years. We derived or adopted age-specific incidence and transition probability data, assuming a natural history progression between the stages of cancer, from other studies. We obtained lifetime direct and indirect treatment costs in 2014 United States dollars (US$) from surveys of breast cancer patients in 37 Chinese hospitals. To calculate QALYs, we derived utility scores from cross-sectional patient surveys. We evaluated incremental cost-effectiveness ratios for various scenarios for comparison with a willingness-to-pay threshold.

findingsOur baseline model of annual screening yielded an incremental cost-effectiveness ratio of US$ 8253/QALY, lower than the willingness-to-pay threshold of US$ 23 050/QALY. One-way and probabilistic sensitivity analyses demonstrated that the results are robust. In the exploration of various scenarios, screening every 3 years is the most cost-effective with an incremental cost-effectiveness ratio of US$ 6671/QALY. The cost-effectiveness of the screening is reduced if not all diagnosed women seek treatment. Finally, the economic benefit of screening women aged 45-69 years with both ultrasound and mammography, compared with mammography alone, is uncertain.

conclusionHigh-risk population-based breast cancer screening is cost-effective compared with no screening.

Indexed as

Quality-Adjusted Life YearsAdultAgedBreast NeoplasmsChinaCost-Benefit AnalysisCross-Sectional StudiesEarly Detection of CancerFemaleHumansInfant, NewbornMass ScreeningMiddle Aged

Identifiers

PMID30104797
PMCPMC6083393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.