Observational studyScientific reports2018
Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.
Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Pooled it
- Iberian Registry of Ocular Syphilis (IBERSOS) report 1: epidemiology, clinical spectrum and treatment outcomes of ocular syphilis in the Iberian Peninsula.The British journal of ophthalmology · 2026Observational
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- Risk factors for ocular complications in HIV/AIDS patients: a retrospective analysis of ophthalmology consultations in a tertiary hospital in Central China.BMC ophthalmology · 2026Article
- Syphilitic Uveitis in HIV-Positive and -Negative Patients: A Multicenter Cohort Study.Turkish journal of ophthalmology · 2026Article
- Ocular Syphilis in Individuals with and Without HIV: A Single-Center University Hospital Experience.Pathogens (Basel, Switzerland) · 2026Article
- Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV.BMC ophthalmology · 2025Article
- Article
- Influence of gender on clinical presentation, management practices and outcomes of ocular syphilis.Scientific reports · 2024Article
- Diagnosis and treatment of syphilitic uveitis: Taiwan experts consensus.Journal of the Chinese Medical Association : JCMA · 2024Article
- Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?Antimicrobial agents and chemotherapy · 2024Article
- Clinical Reasoning: A Woman With Progressive Painless Sequential Monocular Vision Loss.Neurology · 2023Article
- Vision-related quality of life in patients treated for ocular syphilis.Scientific reports · 2023Article
- Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy.Life (Basel, Switzerland) · 2022Article
- Clinical features and incidence of visual improvement following systemic antibiotic treatment in patients with syphilitic uveitis.Scientific reports · 2022Article
- An Eye-Opening Presentation of Syphilis.Cureus · 2022Article
- Pyramidal Inflammatory Deposits of the Retinal Pigment Epithelium and Outer Retina in Ocular Syphilis.Ophthalmology. Retina · 2022Article
- Article
- Neurosyphilis in a suspected case of giant cell arteritis.BMJ case reports · 2021Article
- Classification Criteria for Syphilitic Uveitis.American journal of ophthalmology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports from different world regions suggest ocular syphilis is re-emerging, in parallel with an increasing incidence of the systemic infection globally. We conducted a large observational study of 127 persons consecutively treated for ocular syphilis at public medical centers in Brazil over a 2.5-year period ending July 2015. Of 104 individuals serologically tested for human immunodeficiency virus (HIV), 34.6% were positive. Ophthalmological evaluations included measurement of Snellen visual acuity and intraocular pressure, and assessment of inflammation by slit lamp examination and dilated posterior eye examination. Involvements in 214 eyes were anterior (6.1%), intermediate (8.4%), posterior (76.2%) and pan- (8.4%) uveitis, and scleritis (0.9%). Multiple anterior and posterior eye complications were observed, including cataract in the anterior eye (incidence rate, 0.18/eye-year) and epiretinal membrane in the posterior eye (incidence rate, 0.09/eye-year); incidence rates of reduction in best-corrected visual acuity to ≤20/50 and ≤20/200 were 0.10 and 0.06/eye-year, respectively. Rates of complications and visual acuity loss did not differ significantly between HIV- positive and negative individuals. In an era of re-emergence, syphilis has ocular complications that may compromise vision, despite treatment with appropriate anti-microbial drugs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.