ArticleNature genetics2018
Relatedness disequilibrium regression estimates heritability without environmental bias.
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts.American journal of human genetics · 2021Pooled it
- Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.Translational psychiatry · 2021Pooled it
- Article
- Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.Nature human behaviour · 2026Article
- Exploratory Genome and Transcriptome-Wide Association Analyses of Addiction-Related Phenotypes in a Twin Cohort.Biomedicines · 2026Article
- Separating direct, indirect, and parent-of-origin genetic effects in the human population.Cell genomics · 2026Article
- Direct and Indirect Genetic Effects on Child ADHD Traits in Early and Mid-Childhood: Trio Genome-Wide Complex Trait Analyses in a Large Norwegian Birth Registry Cohort.Behavior genetics · 2026Article
- A generalized test of genotype-phenotype causality in population-sampled nuclear families.PLoS genetics · 2026Article
- On the genetic origins of phenotypes in genome-wide association studies: the SAFE-hBMC bioinformatics · 2026Article
- On the modelling of variance components in classical twin studies.Journal of human genetics · 2026Review
- The rate of identical-by-descent segment sharing between close and distant relatives.HGG advances · 2026Article
- Pitfalls in estimating and interpreting the contribution of ultra-rare genetic variants to the heritability of complex traits.medRxiv : the preprint server for health sciences · 2026Article
- Associations of genetic variants for educational success with risk and time preferences vary by childhood environment.Communications psychology · 2026Article
- The Economics and Econometrics of Gene-Environment Interplay.The Review of economic studies · 2026Article
- Confounding fuels misinterpretation in human genetics.Proceedings. Biological sciences · 2025Article
- Family-GWAS reveals effects of environment and mating on genetic associations.medRxiv : the preprint server for health sciences · 2025Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.Research square · 2025Article
- Separating direct, indirect and parent-of-origin genetic effects in the human population.bioRxiv : the preprint server for biology · 2025Article
- An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference.bioRxiv : the preprint server for biology · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Heritability measures the proportion of trait variation that is due to genetic inheritance. Measurement of heritability is important in the nature-versus-nurture debate. However, existing estimates of heritability may be biased by environmental effects. Here, we introduce relatedness disequilibrium regression (RDR), a novel method for estimating heritability. RDR avoids most sources of environmental bias by exploiting variation in relatedness due to random Mendelian segregation. We used a sample of 54,888 Icelanders who had both parents genotyped to estimate the heritability of 14 traits, including height (55.4%, s.e. 4.4%) and educational attainment (17.0%, s.e. 9.4%). Our results suggest that some other estimates of heritability may be inflated by environmental effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.