Evidence map›Paper›PMID 30104734›Full record

ArticleNature neuroscience2018

Voluntary urination control by brainstem neurons that relax the urethral sphincter.

Jason A Keller, Jingyi Chen, Sierra Simpson, Eric Hou-Jen Wang, Varoth Lilascharoen, Olivier George, Byung Kook Lim, Lisa Stowers

Abstract read
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 110 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Review
  6. Spoti-find: a novel, open-source void spot assay image analysis tool.American journal of physiology. Renal physiology · 2026
    Article
  7. bioRxiv : the preprint server for biology · 2026
    Article
  8. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jason A KellerDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9839-7293
Jingyi ChenDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Sierra SimpsonDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1352-0617
Eric Hou-Jen WangBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
Varoth LilascharoenBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9732-9966
Olivier GeorgeDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3700-5003
Byung Kook LimNeurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3766-5415
Lisa StowersDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. stowers@scripps.edu.ORCID http://orcid.org/0000-0002-4403-1269
Scripps Research Institute · USUniversity of California San Diego · US

Funding

Neurosciences Graduate Training ProgramT32NS061847 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Brenda L Bloodgood · 2008 to 2026
$7.7M
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuitR01NS108439 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI STOWERS, LISA · 2018 to 2022
$3.5M
Stress modulation of olfactory sensationR01DC015253 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI STOWERS, LISA · 2017 to 2021
$3.2M
NIDCD NIH HHS R01 DC015253NINDS NIH HHS R01 NS108439NINDS NIH HHS T32 NS061847
6 · The paper itself

Abstract

Voluntary urination ensures that waste is eliminated when safe and socially appropriate, even without a pressing urge. Uncontrolled urination, or incontinence, is a common problem with few treatment options. Normal urine release requires a small region in the brainstem known as Barrington's nucleus (Bar), but specific neurons that relax the urethral sphincter and enable urine flow are unknown. Here we identify a small subset of Bar neurons that control the urethral sphincter in mice. These excitatory neurons express estrogen receptor 1 (Bar

Indexed as

AnimalsBrain StemElectromyographyEstrogen Receptor alphaMaleMiceNeural PathwaysNeuronsOdorantsOptogeneticsUrethraUrinationUrination DisordersEstrogen Receptor alpha

Identifiers

PMID30104734
PMCPMC6119086
OpenAlexW2887711694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.