ArticleNature neuroscience2018
Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.
Abstract read
In one paragraph
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Homozygous CHD8 mutation intensifies ASD phenotypes and attenuates sex differences.Molecular psychiatry · 2026Article
- USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.Molecules and cells · 2026Article
- Male-Biased Social Deficits in Chd8Neuroscience bulletin · 2026Article
- Article
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency.Science advances · 2026Article
- Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Article
- Chromodomain helicase DNA-binding proteins and orofacial cleft.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Review
- Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development.Cell genomics · 2025Article
- Persistent cortical excitatory neuron dysregulation in adultResearch square · 2025Article
- CHD8 adulthood microglial knockdown in C57BL6 mice induces behavioral, morphological, and transcriptional changes in a sex-dependent manner.Translational psychiatry · 2025Article
- Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice.Nature communications · 2025Article
- Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders.iScience · 2025Review
- Role of androgen receptors in sexually dimorphic phenotypes in UBE3A-dependent autism spectrum disorder.iScience · 2025Article
- The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice.Journal of molecular neuroscience : MN · 2024Article
- Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis ofHeliyon · 2024Article
- Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.Nature communications · 2024Article
- The complex etiology of autism spectrum disorder due to missense mutations of CHD8.Molecular psychiatry · 2024Article
- Sexually dimorphic phenotypes and the role of androgen receptors in UBE3A-dependent autism spectrum disorder.bioRxiv : the preprint server for biology · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
29 authors at 7 institutions in 2 countries.
Hwajin JungCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Haram ParkDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Yeonsoo ChoiDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Hyojin KangSupercomputing Center, KISTI, Daejeon, Korea.
Eunee LeeCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Hanseul KweonDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Junyeop Daniel RohDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Jacob EllegoodMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-1504-3321
Woochul ChoiProgram of Brain and Cognitive Engineering, Department of Bio and Brain Engineering, KAIST, Daejeon, Korea.
Jaeseung KangDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Issac RhimCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Su-Yeon ChoiCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Mihyun BaeCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Sun-Gyun KimCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Jiseok LeeCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Changuk ChungDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Taesun YooDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Hanwool ParkGraduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Yangsik KimGraduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.ORCID http://orcid.org/0000-0003-1841-727X
Seungmin HaDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Seung Min UmDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.
Seojung MoDepartment of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University, Seoul, Korea.
Yonghan KwonDepartment of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea.ORCID http://orcid.org/0000-0002-0943-5057
Won MahDepartment of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Yong Chul BaeDepartment of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Hyun KimDepartment of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University, Seoul, Korea.
Jason P LerchMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Se-Bum PaikProgram of Brain and Cognitive Engineering, Department of Bio and Brain Engineering, KAIST, Daejeon, Korea.ORCID http://orcid.org/0000-0002-4078-305X
Eunjoon KimCenter for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea. kime@kaist.ac.kr.ORCID http://orcid.org/0000-0001-5518-6584
Korea Advanced Institute of Science and Technology · KRInstitute for Basic Science · KRKorea University · KRKyungpook National University · KRHospital for Sick Children · CAKorea Institute of Science & Technology Information · KRUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorders (ASDs) are four times more common in males than in females, but the underlying mechanisms are poorly understood. We characterized sexually dimorphic changes in mice carrying a heterozygous mutation in Chd8 (Chd8
Indexed as
Sex CharacteristicsAnimalsAnxiety, SeparationBehavior, AnimalDNA-Binding ProteinsExtracellular MatrixFemaleGene ExpressionHippocampusMaleMiceMice, Inbred C57BLNeuronsObject AttachmentSignal TransductionSocial BehaviorDNA-Binding Proteinsduplin protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.