Evidence map›Paper›PMID 30104698›Full record

SynthesisScientific reports2018

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis.

Ada Ng, Wilson W Tam, Melvyn W Zhang, Cyrus S Ho, Syeda F Husain, Roger S McIntyre, Roger C Ho

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 323 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
323citing papers in PubMed, 12 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

323 citing papers in PubMed, 12 syntheses or guidelines pooled it, 568 citations in OpenAlex.

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  11. Association between Periodontal Disease and Cognitive Impairment in Adults.International journal of environmental research and public health · 2023
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  20. Role of aging‑related cytokines in neurodegenerative disease (Review).International journal of molecular medicine · 2026
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263 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ada NgDepartment of Internal Medicine, National University Health System, Singapore, Singapore.
Wilson W TamAlice Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Melvyn W ZhangBiomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore, Singapore.
Cyrus S HoDepartment of Psychological Medicine, National University Health System, Singapore, Singapore. Su_hui_ho@nuhs.edu.sg.
Syeda F HusainBiomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore, Singapore.
Roger S McIntyreInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Roger C HoDepartment of Internal Medicine, National University Health System, Singapore, Singapore.
National University Health System · SGNational University of Singapore · SGUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer's disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer's disease and 14363 Controls) were included. Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078-1.206; significant heterogeneity: I

Indexed as

Adaptor Proteins, Signal TransducingAgedAlzheimer DiseaseC-Reactive ProteinDepressionDepressive DisorderHumansInflammationInterleukin-1betaInterleukin-6Middle AgedProteinsAdaptor Proteins, Signal TransducingC-Reactive ProteinIL1B protein, humanIL6 protein, humanInterleukin-1betaInterleukin-6ProteinsTNFAIP1 protein, human

Identifiers

PMID30104698
PMCPMC6089986
OpenAlexW2886676544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.