Evidence map›Paper›PMID 30104690›Full record

ReviewNature reviews. Microbiology2018

Targeting mechanisms of tailed bacteriophages.

Franklin L Nobrega, Marnix Vlot, Patrick A de Jonge, Lisa L Dreesens, Hubertus J E Beaumont, Rob Lavigne, Bas E Dutilh, Stan J J Brouns

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 331 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 1 pooled it
31.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 1 synthesis or guideline pooled it, 574 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  9. mBio · 2026
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  16. Harnessing a Lytic (Biology · 2026
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  20. Review

271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Franklin L NobregaDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
Marnix VlotLaboratory of Microbiology, Wageningen University, Wageningen, Netherlands.
Patrick A de JongeDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
Lisa L DreesensDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
Hubertus J E BeaumontDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
Rob LavigneLaboratory of Gene Technology, KU Leuven, Leuven, Belgium.
Bas E DutilhTheoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands.ORCID http://orcid.org/0000-0003-2329-7890
Stan J J BrounsDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands. stanbrouns@gmail.com.
Delft University of Technology · NLWageningen University & Research · NLKU Leuven · BEUniversidade Federal do Rio de Janeiro · BRUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure-function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.

Indexed as

Genetic VariationBacteriaBacteriophagesHost SpecificityProtein Binding

Identifiers

PMID30104690
OpenAlexW2886168820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.