ArticleNature communications2018
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Aging Enhances Serotonergic Signaling via 5-HTAging cell · 2026Article
- Spinal and supraspinal mechanisms of chronic itch: from neuronal circuits to the neuro-immune-microbial axis.Frontiers in medicine · 2026Review
- Article
- γ1 GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAPharmacology & therapeutics · 2022Review
- GABACells · 2022Article
- Analgesic effect of gastrin-releasing peptide in the dorsal horn.Molecular pain · 2022Article
- Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex.Neuroscience bulletin · 2021Article
- Article
- Emerging Therapeutic Options for Chronic Pruritus.American journal of clinical dermatology · 2020Review
- Central circuit mechanisms of itch.Nature communications · 2020Review
- Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch.British journal of pharmacology · 2020Review
- A New Generation of Treatments for Itch.Acta dermato-venereologica · 2020Review
- Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds.Genetics, selection, evolution : GSE · 2019Article
- Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition.Scientific reports · 2019Article
- Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord.Scientific reports · 2019Article
- Spinal GABABritish journal of anaesthesia · 2019Article
- Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical γ-Power Mediated by α1- and α2-GABAInternational journal of molecular sciences · 2019Article
- Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.Cell reports · 2019Article
- Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacological targeting of inhibitory α2 and α3GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.